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What Alcohol Does to Your Body, Brain & Health

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

In this episode, I discuss the physiological effects that drinking alcohol has on the brain and body at different levels of consumption and over time. I also describe genetic differences that predispose certain individuals to alcoholism, binge and habit-drinking. I explain alcohol metabolism in simple terms and how it effectively acts as a poison, leading to cellular stress and damage. I then explain that it impacts neuronal function and changes our thinking and behavior – hallmarks of inebriation. I also discuss how alcohol consumption of different amounts impacts inflammation, stress, neurodegeneration, and cancer risk and negatively impacts the gut microbiome, brain thickness, hormone balance, mood and feelings of motivation. Additionally, I discuss the biology of hangovers and describe science-based strategies to mitigate the severity of a hangover. Since alcohol is one of the most widely consumed recreational substances, this episode ought to be of relevance to everyone.  Indeed, even low-to-moderate alcohol consumption negatively impacts the brain and body in direct ways. The goal of this episode is to help people make informed decisions about their alcohol consumption that are in keeping with their mental and physical health goals. 
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1 (Athletic Greens): https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/huberman
Supplements from Momentous
https://www.livemomentous.com/huberman
Timestamps
(00:00:00) Effects of Alcohol Consumption
(00:03:19) Low to Moderate Alcohol Consumption & Neurodegeneration 
(00:06:14) Sponsors: AG1, LMNT
(00:10:46) Historical Context & Uses of Alcohol 
(00:13:28) Alcohol Metabolism, “Empty Calories” 
(00:18:23) Inebriation: Top-Down Inhibition, Impulsivity & Memory Formation
(00:24:23) Long-Lasting Effects & Impulsivity, Neuroplasticity & Reversibility 
(00:27:55) Food & Alcohol Absorption
(00:30:07) Alcohol & Serotonin, SSRIs & Depression, Risk for Alcoholism, Blackouts
(00:37:39) Predisposition for Alcoholism; Chronic Consumption, Cortisol & Stress
(00:43:29) Sponsor: AG1
(00:46:07) Genetic Predisposition for Alcoholism, Consuming Alcohol Too Young
(00:52:27) Gut-Liver-Brain Axis: Alcohol, Gut Microbiome, Inflammation & Leaky Gut 
(00:59:46) Tool: Improving/Replenishing Gut Microbiome 
(01:02:44) Reducing Alcohol Consumption & Stress 
(01:04:25) Hangover: Alcohol & Sleep, Anxiety, Headache
(01:12:11) Hangover Recovery, Adrenaline & Deliberate Cold Exposure 
(01:17:16) Hangover Recovery, Dehydration & Electrolytes
(01:20:45) Types of Alcohol & Hangover Severity, Congeners  
(01:25:25) Alcohol Tolerance, Dopamine & Serotonin, Pleasure-Pain Balance   
(01:33:36) Are There Any Positive Effects of Alcohol?, Resveratrol 
(01:35:42) Alcohol & Brain Thickness 
(01:37:11) Alcohol & Cancer Risk: DNA Methylation, Breast Cancer Risk 
(01:44:31) Mitigating Cancer Risk, Folate, B Vitamins 
(01:46:54) Alcohol & Pregnancy, Fetal Alcohol Syndrome 
(01:50:58) Hormones: Testosterone & Estrogen Balance
(01:55:09) Negative Effects of Alcohol Consumption 
(01:58:35) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips
Title Card Photo Credit: Mike Blabac
Disclaimer

In this episode, I discuss the physiological effects that drinking alcohol has on the brain and body at different levels of consumption and over time. I also describe genetic differences that predispose certain individuals to alcoholism, binge and habit-drinking. I explain alcohol metabolism in simple terms and how it effectively acts as a poison, leading to cellular stress and damage. I then explain that it impacts neuronal function and changes our thinking and behavior – hallmarks of inebriation. I also discuss how alcohol consumption of different amounts impacts inflammation, stress, neurodegeneration, and cancer risk and negatively impacts the gut microbiome, brain thickness, hormone balance, mood and feelings of motivation. Additionally, I discuss the biology of hangovers and describe science-based strategies to mitigate the severity of a hangover. Since alcohol is one of the most widely consumed recreational substances, this episode ought to be of relevance to everyone.  Indeed, even low-to-moderate alcohol consumption negatively impacts the brain and body in direct ways. The goal of this episode is to help people make informed decisions about their alcohol consumption that are in keeping with their mental and physical health goals. 
Access the full show notes for this episode at hubermanlab.com.
Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode.
Thank you to our sponsors
AG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/hubermanlab
Waking Up: https://wakingup.com/huberman
Momentous: https://livemomentous.com/huberman
Timestamps
00:00:00 Effects of Alcohol Consumption
00:03:19 Low to Moderate Alcohol Consumption & Neurodegeneration
00:06:14 Sponsors: AG1, LMNT
00:10:46 Historical Context & Uses of Alcohol
00:13:28 Alcohol Metabolism, “Empty Calories”
00:18:23 Inebriation: Top-Down Inhibition, Impulsivity & Memory Formation
00:24:23 Long-Lasting Effects & Impulsivity, Neuroplasticity & Reversibility
00:27:55 Food & Alcohol Absorption
00:30:07 Alcohol & Serotonin, SSRIs & Depression, Risk for Alcoholism, Blackouts
00:37:39 Predisposition for Alcoholism; Chronic Consumption, Cortisol & Stress
00:43:29 Sponsor: AG1
00:46:07 Genetic Predisposition for Alcoholism, Consuming Alcohol Too Young
00:52:27 Gut-Liver-Brain Axis: Alcohol, Gut Microbiome, Inflammation & Leaky Gut
00:59:46 Tool: Improving/Replenishing Gut Microbiome
01:02:44 Reducing Alcohol Consumption & Stress
01:04:25 Hangover: Alcohol & Sleep, Anxiety, Headache
01:12:11 Hangover Recovery, Adrenaline & Deliberate Cold Exposure
01:17:16 Hangover Recovery, Dehydration & Electrolytes
01:20:45 Types of Alcohol & Hangover Severity, Congeners
01:25:25 Alcohol Tolerance, Dopamine & Serotonin, Pleasure-Pain Balance
01:33:36 Are There Any Positive Effects of Alcohol?, Resveratrol
01:35:42 Alcohol & Brain Thickness
01:37:11 Alcohol & Cancer Risk: DNA Methylation, Breast Cancer Risk
01:44:31 Mitigating Cancer Risk, Folate, B Vitamins
01:46:54 Alcohol & Pregnancy, Fetal Alcohol Syndrome
01:50:58 Hormones: Testosterone & Estrogen Balance
01:55:09 Negative Effects of Alcohol Consumption
01:58:35 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips
Disclaimer
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