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Using Stem Cells to Cure Autism, Epilepsy & Schizophrenia | Dr. Sergiu Pașca

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

My guest is Dr. Sergiu Pașca, MD, professor of psychiatry and behavioral sciences at Stanford University. We discuss the biology and genetics of autism, why autism diagnoses are increasing and recent progress in using stem cells to understand and treat profound autism and other brain disorders. Dr. Pașca explains “organoids and assembloids”—human stem cell–derived tools he pioneered to study, treat and cure complex brain diseases. We also discuss ethical and safety issues with using gene editing and stem cells in humans.

Read the episode show notes at hubermanlab.com.

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Timestamps

(00:00) Sergiu Pașca

(02:08) Autism Spectrum Disorder, Incidence, Genetics

(07:16) Is Autism More Common in Males?

(09:35) Sponsors: David & Helix Sleep

(11:56) Eye Contact in Babies, Fever; Proposed Causes of Autism; Genes

(18:48) Genetic or Idiopathic Autism Diagnoses, Timothy Syndrome

(21:37) Rise in Autism Diagnoses

(26:46) Cause, Correlation & Neurological Disease; Schizophrenia, Do Vaccines Cause Autism?

(31:34) Global Increase in Autism; Gene Therapy, CRISPR, Follistatin

(41:05) Sponsors: AG1 & BetterHelp

(43:41) Stem Cells, Ethics, Yamanaka Factors, Human Stem Cell Models

(52:03) Umbilical Stem Cells; Stem Cell Injections & Dangers, Autistic Kids

(59:30) Organoids, Modeling Brain Development, Intrinsic Development Timer

(1:12:22) Assembloids, Brain Cell Migration & Circuit Formation, Self-Organization

(1:21:22) Four-Part Assembloid, Sensory Assembloid, Pain Conditions

(1:25:45) Sponsor: Function

(1:27:33) Future Medical Therapies, Cell Banking, Immortalize Tissues, Rejuvenate Cells

(1:34:56) Assembloids & Ethics, Importance of Nomenclature, Science Collaboration & Self-Correction

(1:45:38) Cell Transplantation & Ethics, Timing

(1:55:05) Genetic Testing for Parents, Genetic Penetrance

(2:02:36) Assembloids, Timothy Syndrome, Epilepsy, Schizophrenia, Dystonia

(2:14:30) Scientific Career, Walking, Art, Medical School

(2:20:44) Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter

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