Using Existing Drugs in New Ways to Treat & Cure Diseases of Brain & Body | Dr. David Fajgenbaum
Huberman Lab
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1 hod 58 min
My guest is Dr. David Fajgenbaum, MD, professor of translational medicine and human genetics at the University of Pennsylvania. He explains how, unbeknownst to most doctors, many approved medications can successfully treat or even cure diseases other than the ones they are typically used to treat. He shares his story of escaping death from Castleman's disease by discovering a life-saving treatment using repurposed drugs that were approved for other purposes. Our conversation explores how researchers, physicians, and you—the general public—can explore novel treatments and cures to conditions the medical profession has deemed untreatable, including cancers. We also discuss the crucial role of mindset in battling diseases and the lesser-known use of compounds to promote health and longevity.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AGZ by AG1: https://drinkagz.com/huberman
Eight Sleep: https://eightsleep.com/huberman
Rorra: https://rorra.com/huberman
David: https://davidprotein.com/huberman
Function: https://functionhealth.com/huberman
Timestamps
(0:00) David Fajgenbaum
(4:06) Self-Agency in Healthcare; New Uses for Old Medicines
(6:44) Other Uses of Aspirin & Viagra; Drug Development & Approved Use
(8:53) Lidocaine & Breast Cancer; Pharmaceutical Companies & Incentives
(11:36) Sponsors: Eight Sleep & Rorra
(14:16) Pharmaceutical Companies, Patents & New Uses; Lithium
(18:40) Tools: Finding Reliable Health Sources, Asking Questions & Disease Organizations; DADA2 Treatment
(21:53) Medical Community & Connections; Integrated Medical Databases
(24:36) Drug Repurposing, Thalidomide, Pembrolizumab
(28:45) Medical Research Databases, Mapping Disease Connections
(33:51) Every Cure Database & Programs, Bachmann-Bupp Syndrome; Colchicine & Heart Disease
(37:57) Sponsors: AGZ by AG1 & David
(40:41) David’s Medical & Career Journey, Glioblastoma, Castleman Disease
(49:10) Autoimmune Disease, Driven Personality, Stress & Immune System
(52:52) Castleman Disease, Treatment, Chemotherapy
(55:54) Physician Continuing Education, Santa Claus Theory of Civilization; Science Collaboration
(1:03:32) Medical School, Relapse & “Overtime”, Finding a New Treatment, Rapamycin
(1:12:46) Sport, Football & Resilience; Challenge & Personal Growth, Family
(1:18:41) Sponsor: Function
(1:20:29) Social Support; “Overtime”, Gratitude
(1:23:19) Business School, Castleman Disease Treatment; Repurposing Drugs & AI
(1:28:29) Drug Repurposing, POEMS Syndrome; Mitigating Risk
(1:35:32) Nicotine, Compounds for Preventive Health; GLP-1 Agonists
(1:40:51) Bioprospecting, Drug Development; AI, Prioritization & Novel Connections
(1:46:18) Healthcare & Children; Hope, Action & Impact Circuit; Challenge & Super-Agers
(1:52:50) Get Involved with Every Cure
(1:56:20) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
Disclaimer & Disclosures
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Popis podcastu
The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017.
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.