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The Science & Treatment of Obsessive-Compulsive Disorder (OCD)

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

In this episode, I explain the biology and psychology of obsessive-compulsive disorder (OCD)—a prevalent and debilitating condition. I also discuss the efficacy and mechanisms behind OCD treatments—both behavioral and pharmacologic as well as holistic and combination treatments and new emerging treatments, including directed brain stimulation. I explain the neural circuitry underlying repetitive “thought-action loops” and why in OCD, the compulsive actions merely make the obsessions even stronger. I review cognitive-behavioral therapies like exposure therapy and SSRIs, holistic approaches, and nutraceuticals, detailing the efficacy of each approach and what science says about how to combine and sequence treatments. I describe an often effective approach for treating OCD where clinicians use cognitive behavioral therapy (CBT) to deliberately bring patients into states of high anxiety while encouraging them to suppress compulsive actions in order to help them learn to overcome repetitious thought/action cycles. This episode should interest anyone with OCD, anyone who knows someone with OCD or OCPD, and more generally, those interested in how the brain works to control thoughts and actions, whether those thoughts are intrusive or not.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1 (Athletic Greens): https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/huberman
Supplements from Momentous
https://www.livemomentous.com/huberman
Timestamps
(00:00:00) Obsessive-Compulsive Disorder (OCD)
(00:04:06) Sponsors: AG1, LMNT
(00:08:28) What is OCD and Obsessive-Compulsive Personality Disorder?
(00:11:18) OCD: Major Incidence & Severity
(00:15:10) Categories of OCD
(00:21:33) Anxiety: Linking Obsessions & Compulsions
(00:27:33) OCD & Familial Heredity
(00:29:10) Biological Mechanisms of OCD, Cortico-Striatal-Thalamic Loops
(00:39:36) Cortico-Striatal-Thalamic Loop & OCD
(00:46:39) Clinical OCD Diagnosis, Y-BOCS Index
(00:51:38) OCD & Fear, Cognitive Behavioral Therapy (CBT) & Exposure Therapy
(01:01:56) Unique Characteristics of CBT/Exposure Therapy in OCD Treatment
(01:10:18) CBT/Exposure Therapy & Selective Serotonin Reuptake Inhibitors (SSRIs)
(01:22:30) Considerations with SSRIs & Prescription Drug Treatments
(01:25:17) Serotonin & Cognitive Flexibility, Psilocybin Studies
(01:31:50) Neuroleptics & Neuromodulators
(01:36:09) OCD & Cannabis, THC & CBD
(01:39:29) Ketamine Treatment
(01:41:43) Transcranial Magnetic Stimulation (TMS)
(01:46:22) Cannabis CBD & Focus
(01:47:50) Thoughts Are Not Actions
(01:51:27) Hormones, Cortisol, DHEA, Testosterone & GABA
(02:00:55) Holistic Treatments: Mindfulness Meditation & OCD
(02:03:28) Nutraceuticals & Supplements: Myo-Inositol, Glycine
(02:09:45) OCD vs. Obsessive-Compulsive Personality Disorder
(02:20:53) Superstitions, Compulsions & Obsessions
(02:31:00) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac
Disclaimer

In this episode, I explain the biology and psychology of obsessive-compulsive disorder (OCD)—a prevalent and debilitating condition. I also discuss the efficacy and mechanisms behind OCD treatments—both behavioral and pharmacologic as well as holistic and combination treatments and new emerging treatments, including directed brain stimulation. I explain the neural circuitry underlying repetitive “thought-action loops” and why in OCD, the compulsive actions merely make the obsessions even stronger. I review cognitive-behavioral therapies like exposure therapy and SSRIs, holistic approaches, and nutraceuticals, detailing the efficacy of each approach and what science says about how to combine and sequence treatments. I describe an often effective approach for treating OCD where clinicians use cognitive behavioral therapy (CBT) to deliberately bring patients into states of high anxiety while encouraging them to suppress compulsive actions in order to help them learn to overcome repetitious thought/action cycles. This episode should interest anyone with OCD, anyone who knows someone with OCD or OCPD, and more generally, those interested in how the brain works to control thoughts and actions, whether those thoughts are intrusive or not.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/hubermanlab
Waking Up: https://wakingup.com/huberman
Momentous: https://livemomentous.com/huberman
Timestamps
(00:00:00) Obsessive-Compulsive Disorder (OCD)
(00:04:06) Sponsors: AG1, LMNT
(00:08:28) What is OCD and Obsessive-Compulsive Personality Disorder?
(00:11:18) OCD: Major Incidence & Severity
(00:15:10) Categories of OCD
(00:21:33) Anxiety: Linking Obsessions & Compulsions
(00:27:33) OCD & Familial Heredity
(00:29:10) Biological Mechanisms of OCD, Cortico-Striatal-Thalamic Loops
(00:39:36) Cortico-Striatal-Thalamic Loop & OCD
(00:46:39) Clinical OCD Diagnosis, Y-BOCS Index
(00:51:38) OCD & Fear, Cognitive Behavioral Therapy (CBT) & Exposure Therapy
(01:01:56) Unique Characteristics of CBT/Exposure Therapy in OCD Treatment
(01:10:18) CBT/Exposure Therapy & Selective Serotonin Reuptake Inhibitors (SSRIs)
(01:22:30) Considerations with SSRIs & Prescription Drug Treatments
(01:25:17) Serotonin & Cognitive Flexibility, Psilocybin Studies
(01:31:50) Neuroleptics & Neuromodulators
(01:36:09) OCD & Cannabis, THC & CBD
(01:39:29) Ketamine Treatment
(01:41:43) Transcranial Magnetic Stimulation (TMS)
(01:46:22) Cannabis CBD & Focus
(01:47:50) Thoughts Are Not Actions
(01:51:27) Hormones, Cortisol, DHEA, Testosterone & GABA
(02:00:55) Holistic Treatments: Mindfulness Meditation & OCD
(02:03:28) Nutraceuticals & Supplements: Myo-Inositol, Glycine
(02:09:45) OCD vs. Obsessive-Compulsive Personality Disorder
(02:20:53) Superstitions, Compulsions & Obsessions
(02:31:00) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter
Disclaimer
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