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How Hormones Shape Sexual Development

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

In this episode, I discuss how hormones such as testosterone and estrogen and their derivatives impact the early development of the brain and body and their maturation. I review published data on environmental factors shown to powerfully alter hormone pathways in animals and humans and the effects of cannabis, alcohol and cell phones on testes, sperm, ovaries and hormones. I describe the predictable relationship between genes, beard growth and balding patterns, and the importance of estrogen for brain development in people of all chromosomal sexes. Finally, I discuss how the hormones we are exposed to in the womb shape the relative length of our finger digits, the sounds our ears make (yes you read that correctly), and how those correlate with people's self-reports of their sexual preferences. As always, basic information and tools are discussed.
Access the full show notes, including referenced articles, resources and more at hubermanlab.com.
Thank you to our sponsors
AG1 (Athletic Greens): https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/huberman
Waking Up: https://www.wakingup.com/huberman
Momentous: https://www.livemomentous.com/huberman
Timestamps
(00:00:00) Introduction
(00:00:30) AG1, LMNT & Waking Up
(00:06:47) Announcement: Mood Meter App Works Again
(00:08:00) Maximizing Learning from the Podcast
(00:10:00) New Non-Sleep Deep Rest Protocol, Spanish Subtitles
(00:11:35) Sexual Differentiation: Hormones, Neurons & Behavior
(00:14:15) Hormones Basics
(00:15:26) Sperm Meets Egg, Chromosomal Sex, Gonadal Sex,
(00:17:50) Y Chromosome Inhibition of Feminization
(00:19:00) Placenta Is An Endocrine (Hormone-Producing) Organ, Adrenal Testosterone
(00:19:45) Hormonal Sex, Morphological Sex
(00:21:04) Hormones Fast & Slow, Sex Steroids Can Turn On Genes
(00:23:06) Masculinization, Feminization, Demasculinization, Defeminization
(00:23:42) Primary Sexual Characteristics: DHT Drives Penis Development
(00:27:03) Secondary Sexual Characteristics
(00:27:43) Penis Sprouting: Guevedoces
(00:31:25) Estrogen, NOT Testosterone, Masculinizes The Brain
(00:33:15) Breast Development In Males: Aromatase; Puberty, & Steroids in Athletes
(00:34:50) Estrogen Powerfully Controls Brain Development In All Individuals
(00:35:19) Avoiding Hormonal Disruption In Children & Adults: Specific Oils, Creams, Etc.
(00:39:00) Environmental Endocrine Disruptors, Sperm Count Decline, Vincloziline
(00:44:20) Androgen Insensitivity Syndrome: Hormones Need Receptors, SARMS
(00:48:41) Estrogen Establishes “Masculine” Brain Circuits, Testosterone
(00:49:42) Cannabis, Alcohol: In Babies, Puberty & Adults
(00:56:25) Cell Phone Technology: Effects On Hormones, Ovaries, & Testicles
(01:02:33) Beards & Baldness Patterns Around the World, DHT, 5-alpha-reductase
(01:06:39) Creatine & DHT/Hair Loss
(01:08:20) Predicting Aging Rates By Pubertal Rates
(01:10:04) Hyenas, Baseball, & Jumbo Clitorises: Androstenedione
(01:14:26) Intersex Moles
(01:15:40) Marijuana Plants, Pollens: Plant-To-Animal “Warfare”
(01:20:08) Finger Length Ratios, Prenatal Hormone Exposure & Sexual Orientation
(01:29:13) Brain Dimorphisms with Sexual Orientation
(01:32:00) “Older Brother Effects”: Male Fetuses Might Change Mothers & Subsequent Brothers
(01:35:06) The Path Forward & A Warning
(01:35:55) Support & Your Questions
Title Card Photo Credit: Mike Blabac
Disclaimer

In this episode, I discuss how hormones such as testosterone and estrogen and their derivatives impact the early development of the brain and body and their maturation. I review published data on environmental factors shown to powerfully alter hormone pathways in animals and humans and the effects of cannabis, alcohol and cell phones on testes, sperm, ovaries and hormones. I describe the predictable relationship between genes, beard growth and balding patterns, and the importance of estrogen for brain development in people of all chromosomal sexes. Finally, I discuss how the hormones we are exposed to in the womb shape the relative length of our finger digits, the sounds our ears make (yes you read that correctly), and how those correlate with people's self-reports of their sexual preferences. As always, basic information and tools are discussed.

Read the full show notes for this episode at hubermanlab.com.

Thank you to our sponsors

AG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/hubermanlab
Waking Up: https://www.wakingup.com/huberman

Timestamps
00:00:00 Introduction  
00:00:30 AG1, LMNT & Waking Up  
00:06:47 Announcement: Mood Meter App Works Again  
00:08:00 Maximizing Learning from the Podcast  
00:10:00 New Non-Sleep Deep Rest Protocol, Spanish Subtitles  
00:11:35 Sexual Differentiation: Hormones, Neurons & Behavior  
00:14:15 Hormones Basics  
00:15:26 Sperm Meets Egg, Chromosomal Sex, Gonadal Sex  
00:17:50 Y Chromosome Inhibition of Feminization  
00:19:00 Placenta Is An Endocrine (Hormone-Producing) Organ, Adrenal Testosterone  
00:19:45 Hormonal Sex, Morphological Sex  
00:21:04 Hormones Fast & Slow, Sex Steroids Can Turn On Genes  
00:23:06 Masculinization, Feminization, Demasculinization, Defeminization  
00:23:42 Primary Sexual Characteristics: DHT Drives Penis Development  
00:27:03 Secondary Sexual Characteristics  
00:27:43 Penis Sprouting: Guevedoces  
00:31:25 Estrogen, NOT Testosterone, Masculinizes The Brain  
00:33:15 Breast Development In Males: Aromatase; Puberty, & Steroids in Athletes  
00:34:50 Estrogen Powerfully Controls Brain Development In All Individuals  
00:35:19 Avoiding Hormonal Disruption In Children & Adults: Specific Oils, Creams, Etc.  
00:39:00 Environmental Endocrine Disruptors, Sperm Count Decline, Vincloziline  
00:44:20 Androgen Insensitivity Syndrome: Hormones Need Receptors, SARMS  
00:48:41 Estrogen Establishes “Masculine” Brain Circuits, Testosterone  
00:49:42 Cannabis, Alcohol: In Babies, Puberty & Adults  
00:56:25 Cell Phone Technology: Effects On Hormones, Ovaries, & Testicles  
01:02:33 Beards & Baldness Patterns Around the World, DHT, 5-alpha-reductase  
01:06:39 Creatine & DHT/Hair Loss  
01:08:20 Predicting Aging Rates By Pubertal Rates  
01:10:04 Hyenas, Baseball, & Jumbo Clitorises: Androstenedione  
01:14:26 Intersex Moles  
01:15:40 Marijuana Plants, Pollens: Plant-To-Animal “Warfare”  
01:20:08 Finger Length Ratios, Prenatal Hormone Exposure & Sexual Orientation  
01:29:13 Brain Dimorphisms with Sexual Orientation  
01:32:00 “Older Brother Effects”: Male Fetuses Might Change Mothers & Subsequent Brothers  
01:35:06 The Path Forward & A Warning  
01:35:55 Support & Your Questions  

Disclaimer & Disclosures
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