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The Effects of Cannabis (Marijuana) on the Brain & Body

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

In this episode, I discuss cannabis (aka marijuana), including the biological mechanisms underlying its effects on the mind and body, its known medical applications, its impact on libido, creativity, hunger, hormones and more. I also cover the known adverse health consequences of chronic and even acute (one-time) use and the factors that determine if cannabis is helpful or harmful. Additionally, I detail how the various strains of cannabis: sativa, indica and hybrid strains, can produce such divergent effects depending on the strain type, THC-to-CBD ratio, total dosage, and frequency of use. I review why cannabis can impact speech patterns and one’s propensity to develop anxiety/depression during and after use and, in some individuals, paranoia. As the legal landscape for cannabis is rapidly evolving, this episode should interest a wide audience, including former/current cannabis users, those in the medical, sports, law enforcement, and educational communities and, of course, children, teenagers, and parents.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1 (Athletic Greens): https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/huberman
Supplements from Momentous
https://www.livemomentous.com/huberman
Huberman Lab Premium
https://hubermanlab.com/premium
Timestamps
(00:00:00) Cannabis (Marijuana)
(00:005:02) Sponsor: LMNT
(00:07:03) Tool: Non-Sleep Deep Rest (NSDR), Sleep & Anxiety
(00:15:08) Cannabis Strains, Psychoactive Compounds: THC & CBD
(00:19:34) Sativa vs. Indica, Stimulant vs. Relaxation Effects
(00:25:55) Hybrid Cannabis Strains, Type 1, 2 & 3 Strains
(00:31:56) Naturally Occurring Receptors: Nicotinic & Cannabinoid Receptors (CB1)
(00:35:18) Sponsor: AG1
(00:40:35) THC, CBD vs. Endogenous Cannabinoids, Dependence
(00:43:14) Endogenous Cannabinoids, Cannabinoid Receptors & Nervous System Function
(00:53:07) Biological Effects of Cannabis
(00:56:29) Cannabis Sativa & Subjective Effects: Mood, Stress, Alertness, Paranoia
(01:04:58) Cannabis Indica & Subjective Effects, Memory, Dosage
(01:09:41) Brain Areas Affected by THC & CBD, Side Effects
(01:16:08) Creativity: Convergent vs. Divergent Thinking & Dopamine
(01:26:41) Does Cannabis Increase Creativity?
(01:35:08) Chronic Cannabis Use & Changes in Speech Patterns
(01:46:46) Cannabis & Libido, Dopamine & Prolactin
(01:56:55) Cannabis & Hormones: Prolactin, Testosterone, Estrogen & Fertility
(02:06:53) Smoking/Vaping Tobacco or Cannabis & Negative Health Consequences
(02:10:06) Avoiding Cannabis During Pregnancy/Breastfeeding, Fetal Neural Development
(02:18:13) Negative Health Consequences of Cannabis, Anxiety & Depression, Tolerance
(02:25:57) Cannabis Use & Adolescence/Young Adulthood, Predisposition to Psychosis
(02:34:36) Adolescent Cannabis Use: Brain Development & Mental Health Disorders
(02:41:44) Cannabis & Pain Management, Divergent Effects of Cannabis
(02:44:54) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Huberman Lab Premium, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook, LinkedIn
 Title Card Photo Credit: Mike Blabac
Disclaimer

In this episode, I discuss cannabis (aka marijuana), including the biological mechanisms underlying its effects on the mind and body, its known medical applications, its impact on libido, creativity, hunger, hormones and more. I also cover the known adverse health consequences of chronic and even acute (one-time) use and the factors that determine if cannabis is helpful or harmful. Additionally, I detail how the various strains of cannabis: sativa, indica and hybrid strains, can produce such divergent effects depending on the strain type, THC-to-CBD ratio, total dosage, and frequency of use. I review why cannabis can impact speech patterns and one’s propensity to develop anxiety/depression during and after use and, in some individuals, paranoia. As the legal landscape for cannabis is rapidly evolving, this episode should interest a wide audience, including former/current cannabis users, those in the medical, sports, law enforcement, and educational communities and, of course, children, teenagers, and parents.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/hubermanlab
Waking Up: https://wakingup.com/huberman
Momentous: https://livemomentous.com/huberman
Timestamps
(00:00:00) Cannabis (Marijuana)
(00:005:02) Sponsor: LMNT
(00:07:03) Tool: Non-Sleep Deep Rest (NSDR), Sleep & Anxiety
(00:15:08) Cannabis Strains, Psychoactive Compounds: THC & CBD
(00:19:34) Sativa vs. Indica, Stimulant vs. Relaxation Effects
(00:25:55) Hybrid Cannabis Strains, Type 1, 2 & 3 Strains
(00:31:56) Naturally Occurring Receptors: Nicotinic & Cannabinoid Receptors (CB1)
(00:35:18) Sponsor: AG1
(00:40:35) THC, CBD vs. Endogenous Cannabinoids, Dependence
(00:43:14) Endogenous Cannabinoids, Cannabinoid Receptors & Nervous System Function
(00:53:07) Biological Effects of Cannabis
(00:56:29) Cannabis Sativa & Subjective Effects: Mood, Stress, Alertness, Paranoia
(01:04:58) Cannabis Indica & Subjective Effects, Memory, Dosage
(01:09:41) Brain Areas Affected by THC & CBD, Side Effects
(01:16:08) Creativity: Convergent vs. Divergent Thinking & Dopamine
(01:26:41) Does Cannabis Increase Creativity?
(01:35:08) Chronic Cannabis Use & Changes in Speech Patterns
(01:46:46) Cannabis & Libido, Dopamine & Prolactin
(01:56:55) Cannabis & Hormones: Prolactin, Testosterone, Estrogen & Fertility
(02:06:53) Smoking/Vaping Tobacco or Cannabis & Negative Health Consequences
(02:10:06) Avoiding Cannabis During Pregnancy/Breastfeeding, Fetal Neural Development
(02:18:13) Negative Health Consequences of Cannabis, Anxiety & Depression, Tolerance
(02:25:57) Cannabis Use & Adolescence/Young Adulthood, Predisposition to Psychosis
(02:34:36) Adolescent Cannabis Use: Brain Development & Mental Health Disorders
(02:41:44) Cannabis & Pain Management, Divergent Effects of Cannabis
(02:44:54) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Huberman Lab Premium, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook, LinkedIn
Disclaimer
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