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Nicotine’s Effects on the Brain & Body & How to Quit Smoking or Vaping

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

In this episode, I explain how nicotine impacts the brain and body, including its potent ability to enhance attention, focus, and alertness, increase blood pressure and metabolism and reduce appetite. I discuss nicotine’s ability to increase the action of neurochemicals, including dopamine, norepinephrine, and acetylcholine and activate sympathetic (alertness-promoting) neural circuits. I also discuss common nicotine delivery methods, such as cigarettes, vaping, dip, and snuff, and how they each create their own unique experience and how they, but not nicotine itself, cause cancer and other adverse health effects. I also explain science-based tools to permanently quit smoking cigarettes or vaping, including peer-reviewed clinical hypnosis tools, antidepressants, and alternative nicotine replacement (patches, lozenges, gums etc.). As nicotine is one of the most widely used substances with billions of users — most of whom report wanting to quit — this episode ought to be of interest to former/current nicotine users, those who want to quit smoking or vaping and/or those interested in learning the biology behind how nicotine impacts the brain and body.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1 (Athletic Greens): https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/huberman
Supplements from Momentous
https://www.livemomentous.com/huberman
Timestamps
(00:00:00) Nicotine
(00:03:41) Tool: Brief Daily Meditation & Focus
(00:05:59) The Arrow Model of Focus, Alpha GPC & Garlic Supplements
(00:10:05) Sponsor: LMNT
(00:14:35) Nicotine Effects vs. Methods of Delivery, Acetylcholine
(00:19:55) Where is Nicotine Found? Nicotinic Acetylcholine Receptors
(00:25:12) Nicotine & Effects on the Brain: Appetite, Dopamine & GABA
(00:29:37) Sponsor: AG1
(00:32:11) Nicotine, Acetylcholine & Attentional “Spotlighting”
(00:37:29) Nicotine, Norepinephrine & Alertness/Energy
(00:41:10) Nicotine & Effects on Appetite & Metabolism
(00:46:47) Nicotine & Effects on Body: Sympathetic Tone
(00:51:29) Nicotine & Cognitive Work vs. Physical Performance
(00:55:08) Nicotine Delivery Methods & Side Effects, Young People & Dependency
(00:58:35) Smoking, Vaping, Dipping & Snuffing: Carcinogens & Endothelial Cells
(01:02:34) Smoking, Vaping, Dipping & Snuffing: Negative Impacts on Lifespan & Health
(01:09:23) How to Quit Smoking, Nicotine Cravings & Withdrawal
(01:13:56) Vaping & Nicotine, Rates of Effect Onset, Dopamine, Addiction & Depression
(01:25:06) Tool: Quitting Smoking & Clinical Hypnosis, Reveri
(01:30:16) Bupropion (Wellbutrin) & Quitting Smoking
(01:36:24) Tool: A Nicotine Replacement Schedule to Quit Smoking, Nicotine Patch/Gum
(01:41:52) Tool: Biological Homeostasis & Nicotine Withdrawal, The “First Week” Strategy
(01:51:39) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook
Title Card Photo Credit: Mike Blabac
Disclaimer

In this episode, I explain how nicotine impacts the brain and body, including its potent ability to enhance attention, focus, and alertness, increase blood pressure and metabolism and reduce appetite. I discuss nicotine’s ability to increase the action of neurochemicals, including dopamine, norepinephrine, and acetylcholine and activate sympathetic (alertness-promoting) neural circuits. I also discuss common nicotine delivery methods, such as cigarettes, vaping, dip, and snuff, and how they each create their own unique experience and how they, but not nicotine itself, cause cancer and other adverse health effects. I also explain science-based tools to permanently quit smoking cigarettes or vaping, including peer-reviewed clinical hypnosis tools, antidepressants, and alternative nicotine replacement (patches, lozenges, gums etc.). As nicotine is one of the most widely used substances with billions of users — most of whom report wanting to quit — this episode ought to be of interest to former/current nicotine users, those who want to quit smoking or vaping and/or those interested in learning the biology behind how nicotine impacts the brain and body.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/hubermanlab
Waking Up: https://wakingup.com/huberman
Momentous: https://livemomentous.com/huberman
Timestamps
(00:00:00) Nicotine
(00:03:41) Tool: Brief Daily Meditation & Focus
(00:05:59) The Arrow Model of Focus, Alpha GPC & Garlic Supplements
(00:10:05) Sponsor: LMNT
(00:14:35) Nicotine Effects vs. Methods of Delivery, Acetylcholine
(00:19:55) Where is Nicotine Found? Nicotinic Acetylcholine Receptors
(00:25:12) Nicotine & Effects on the Brain: Appetite, Dopamine & GABA
(00:29:37) Sponsor: AG1
(00:32:11) Nicotine, Acetylcholine & Attentional “Spotlighting”
(00:37:29) Nicotine, Norepinephrine & Alertness/Energy
(00:41:10) Nicotine & Effects on Appetite & Metabolism
(00:46:47) Nicotine & Effects on Body: Sympathetic Tone
(00:51:29) Nicotine & Cognitive Work vs. Physical Performance
(00:55:08) Nicotine Delivery Methods & Side Effects, Young People & Dependency
(00:58:35) Smoking, Vaping, Dipping & Snuffing: Carcinogens & Endothelial Cells
(01:02:34) Smoking, Vaping, Dipping & Snuffing: Negative Impacts on Lifespan & Health
(01:09:23) How to Quit Smoking, Nicotine Cravings & Withdrawal
(01:13:56) Vaping & Nicotine, Rates of Effect Onset, Dopamine, Addiction & Depression
(01:25:06) Tool: Quitting Smoking & Clinical Hypnosis, Reveri
(01:30:16) Bupropion (Wellbutrin) & Quitting Smoking
(01:36:24) Tool: A Nicotine Replacement Schedule to Quit Smoking, Nicotine Patch/Gum
(01:41:52) Tool: Biological Homeostasis & Nicotine Withdrawal, The “First Week” Strategy
(01:51:39) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook
Disclaimer
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