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How to Control Your Sense of Pain & Pleasure

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

This episode I discuss our sense of pain and pleasure: where and how they each arise in our mind and body and various ways to control their intensity. I discuss the science of behavioral tools like acupuncture and hypnosis and directed pressure, including the neural circuits they each activate to modulate our experience of pain or pleasure. I also discuss whole body pain, pain "syndromes" and novel pain relief compounds such as Acetyl-L-Carnitine, SAMe and Agmatine. I discuss neuroplasticity of the pain system and the key role that visual perception plays in pain modulation. Finally, I address the link between dopamine, serotonin, and oxytocin, with arousal, pleasure and pain. As always, both basic science and various protocols are described.
Note: The description of the dorsal root ganglia (DRGs) was intentionally simplified and does not include mention of dorsal horn spinal relay neurons, etc. For an excellent full text review of this anatomy and circuits for touch sensing, please see: https://bit.ly/3jH9CPf
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1 (Athletic Greens): https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/huberman
Supplements from Momentous
https://www.livemomentous.com/huberman
Timestamps
(00:00:00) Skin, Pain, Pleasure 
(00:01:50) Protocol 1: Maximizing Motivation (with Dopamine & Pleasure)
(00:07:29) Sponsors: AG1, LMNT
(00:12:04) Pleasure & Pain, & Skin Sensors 
(00:18:13) Sensing Touch with Your Brain: Magnification of Feet, Hands, Lips, Face, Genitals
(00:22:16) Two-Point Discrimination, Dermatomes
(00:28:11) Thoughts & Genes That Make Physical Pain Worse
(00:33:45) Expectations, Anxiety, & Pain Threshold
(00:40:27) Protocol 2: Cold Sensing Is Relative; Getting Into Cold Water
(00:45:22) Protocol 3: Heat Is Absolute
(00:48:10) Injury & Pain
(00:52:04) Protocol 4: Plasticity of Pain: Key Role of Vision 
(00:58:08) Sensing Disparate Body Parts As Merged
(01:01:00) Pain “Syndromes”, Psychogenic Fever, “Psychosomatics”
(01:04:40) Fibromyalgia, Naltrexone, Protocol 5: Acetyl-L-Carnitine 
(01:12:24) Protocol 6: Agmatine, S-adenosyl-L-methionine (SAMe), L-5-Methyltetrahydrofolate*
(01:17:27) Acupuncture: Mechanism, Non-Responders, Itch & Inflammation
(01:28:20) Laser Photobiomodulation, Protocol 7: Hypnosis (reveri.com) 
(01:30:00) Protocol 8: Pressure-Based Pain Relief, “Gate Theory of Pain (Relief)”
(01:37:53) Redheads & Pain Thresholds, Endogenous Opioids 
(01:44:02) Protocol 8: Love & Pain, Dopamine
(01:49:23) Pleasure & Reproduction, Dopamine & Serotonin, Oxytocin
(01:51:40) Protocol 9: PEA, L-Phenylalanine (Precursor to Tyrosine)
(01:55:40) Contextual Control of Pleasure by Autonomic Arousal, Dopamine Baselines
(01:59:40) Pleasure-Pain Balance
(02:01:24) Protocol 10: Controlling Pleasure, Dopamine & Motivation Over Time
(02:06:40) Protocol 11: Immediate, Non-Goal-Directed Pleasure, PAG 
(02:08:40) Direction of Touch: Pleasure Versus Pain, Arousal & Touch “Sensitivity” 
(02:13:00) Synthesis & How to Conceptualize Pain and Pleasure, Support
Title Card Photo Credit: Mike Blabac
Disclaimer

This episode I discuss our sense of pain and pleasure: where and how they each arise in our mind and body and various ways to control their intensity. I discuss the science of behavioral tools like acupuncture and hypnosis and directed pressure, including the neural circuits they each activate to modulate our experience of pain or pleasure. I also discuss whole body pain, pain "syndromes" and novel pain relief compounds such as Acetyl-L-Carnitine, SAMe and Agmatine. I discuss neuroplasticity of the pain system and the key role that visual perception plays in pain modulation. Finally, I address the link between dopamine, serotonin, and oxytocin, with arousal, pleasure and pain. As always, both basic science and various protocols are described.
Note: The description of the dorsal root ganglia (DRGs) was intentionally simplified and does not include mention of dorsal horn spinal relay neurons, etc. For an excellent full text review of this anatomy and circuits for touch sensing, please see: https://bit.ly/3jH9CPf
Read the full show notes for this episode at hubermanlab.com.
Thank you to our sponsors
AG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/hubermanlab
Waking Up: https://wakingup.com/huberman
Momentous: https://livemomentous.com/huberman
Timestamps
00:00:00 Skin, Pain, Pleasure  
00:01:50 Protocol 1: Maximizing Motivation (with Dopamine & Pleasure)  
00:07:29 Sponsors: AG1, LMNT & Waking Up
00:12:04 Pleasure & Pain, & Skin Sensors  
00:18:13 Sensing Touch with Your Brain: Magnification of Feet, Hands, Lips, Face, Genitals  
00:22:16 Two-Point Discrimination, Dermatomes  
00:28:11 Thoughts & Genes That Make Physical Pain Worse  
00:33:45 Expectations, Anxiety, & Pain Threshold  
00:40:27 Protocol 2: Cold Sensing Is Relative; Getting Into Cold Water  
00:45:22 Protocol 3: Heat Is Absolute  
00:48:10 Injury & Pain  
00:52:04 Protocol 4: Plasticity of Pain: Key Role of Vision  
00:58:08 Sensing Disparate Body Parts As Merged  
01:01:00 Pain “Syndromes”, Psychogenic Fever, “Psychosomatics”  
01:04:40 Fibromyalgia, Naltrexone, Protocol 5: Acetyl-L-Carnitine  
01:12:24 Protocol 6: Agmatine, S-adenosyl-L-methionine (SAMe), L-5-Methyltetrahydrofolate  
01:17:27 Acupuncture: Mechanism, Non-Responders, Itch & Inflammation  
01:28:20 Laser Photobiomodulation, Protocol 7: Hypnosis (reveri.com)  
01:30:00 Protocol 8: Pressure-Based Pain Relief, “Gate Theory of Pain (Relief)”  
01:37:53 Redheads & Pain Thresholds, Endogenous Opioids  
01:44:02 Protocol 8: Love & Pain, Dopamine  
01:49:23 Pleasure & Reproduction, Dopamine & Serotonin, Oxytocin  
01:51:40 Protocol 9: PEA, L-Phenylalanine (Precursor to Tyrosine)  
01:55:40 Contextual Control of Pleasure by Autonomic Arousal, Dopamine Baselines  
01:59:40 Pleasure-Pain Balance  
02:01:24 Protocol 10: Controlling Pleasure, Dopamine & Motivation Over Time  
02:06:40 Protocol 11: Immediate, Non-Goal-Directed Pleasure, PAG  
02:08:40 Direction of Touch: Pleasure Versus Pain, Arousal & Touch “Sensitivity”  
02:13:00 Synthesis & How to Conceptualize Pain and Pleasure, Support  
Disclaimer & Disclosures
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