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Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

My guest is Dr. Chris McCurdy, PhD, FAAPS, professor of medicinal chemistry at the University of Florida and a world expert on the pharmacology of kratom and other plant-derived medicinal compounds. We discuss kratom’s wide-ranging effects, including its use for boosting energy, enhancing mood, managing pain and as a potential opioid substitute, while also explaining its critical safety concerns and addictive potential, especially for kratom-derived/isolate products. We also discuss plant-based compounds more generally for their potential benefits and risks. Dr. McCurdy offers a balanced perspective on kratom and other plant-based and naturally occurring medicinal compounds, highlighting and contrasting their promise for human health with potential serious risks.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

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Timestamps

00:00:00 Chris McCurdy

00:02:51 Kratom (Mitragyna speciosa), Origin, Effects, Low vs High Doses

00:07:19 Sponsors: David Protein & Eight Sleep

00:10:07 Kratom, Traditional Use vs Commercial Kratom Products, Absorption

00:17:00 Kratom Products, Serving Size, Kids; Semi-Synthetics; Tool: Understand Kratom Product Labels

00:23:16 Kratom Products & Various Desired Effects; Physical Dependence

00:32:53 Different Kratom Usage Patterns, Opioid Dependence

00:36:59 Alkaloid Compounds, Nitrogen, Nicotine; Animals & Self-Experimentation

00:47:47 Sponsors: AG1 & ROKA

00:51:05 Medicine Development, Disconnection from Nature, Product Concentrations

00:59:00 Alkaloids & Natural Products, Opium Poppy, Coca Leaf, Tool: Kratom Leaf vs Extracts (Kratom-Derived/Kratom Isolates)

01:09:06 Is It Safe for Kids to Consume Kratom Products?

01:12:19 Kratom, Energy, Mood & Pain Management, Dose; Caffeine 

01:16:56 Respiratory Depression & Kratom Products

01:20:16 Sponsor: Function

01:22:04 Kratom Leaf vs Derivatives, FDA Regulations, Usage Guidelines

01:26:59 Kratom, Alcohol Consumption, Respiratory Failure?

01:29:09 Kratom Alkaloids, Mood & Stimulant Effects, Multiple Pathways for Pain Relief

01:38:17 Plant Alkaloids & Chemical Defense, Kratom & Antifungal Alkaloids; Geckos

01:44:35 White, Red & Brown Vein Kratom, Leaf Processing; Terpenes

01:51:08 Kratom as an Anti-Depressant?; Discontinuing Kratom Use, Opioid Use

01:58:03 Kratom, Drug Interactions & Seizure, Opioids

02:01:51 Cacao Beans, Chocolate

02:09:34 Coca-Cola, Coca Plant & Cocaine, History of Soft Drinks

02:19:49 Career Journey, Pharmacy, Chemistry & Education, Lobelia

02:28:44 Nicotine; Natural Products & Career Journey, Salvia divinorum, Kratom

02:40:22 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter

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Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy

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