Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Huberman Lab
Poslechněte si podcast
Dnes
38 min
In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging.
We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse key aspects of biological aging.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AGZ by AG1: https://drinkagz.com/huberman
David: https://davidprotein.com/huberman
Eight Sleep: https://eightsleep.com/huberman
Timestamps
(0:00) David Sinclair
(0:20) Longevity, Anti-Aging, Aging as a Disease
(2:27) Causes of Aging; Epigenome & Genes
(4:53) CD & Scratches Analogy, DNA, Silencing & Expressing Genes
(6:44) Physical Appearance & Aging
(7:36) Sponsor: David
(8:54) Childhood Development & Aging, Horvath Clock, Accelerate Aging
(11:30) Rates of Puberty & Aging, Growth Hormone
(12:37) Body Size & Longevity; Epigenetics
(13:07) Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose
(16:31) Tool: Skip a Meal
(17:07) Longer Fasts & Autophagy, “Deep Cleanse”
(18:07) Sponsor: AGZ by AG1
(19:36) Fasting, Fluids, Electrolytes
(20:16) Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors
(24:24) Breaking a Fast, Tools: Do Your Best; Transitions
(27:00) Sirtuins, NAD, NMN Supplementation
(29:04) Sponsor: Eight Sleep
(31:10) Iron & Senescent Cells; Personalize Medicine
(32:40) Tool: Blood Markers, CRP
(34:50) Tool: Aerobic & Resistance Exercise
(35:55) Estrogen, Fasting & Fertility; Aging & Rejuvenation
(38:20) Acknowledgements
Disclaimer & Disclosures
Learn more about your ad choices. Visit megaphone.fm/adchoices
Popis podcastu
The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017.
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.