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Essentials: How to Optimize Female Hormone Health for Vitality & Longevity | Dr. Sara Gottfried

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

In this Huberman Lab Essentials episode, my guest is Dr. Sara Gottfried, M.D., a Harvard-trained, board-certified gynecologist and expert in female hormone health. We discuss the key biomarkers women should track at each stage of life and how cortisol, thyroid hormone, estrogen, progesterone, and testosterone shape energy, mood, metabolism, and long-term disease risk. We also discuss PCOS, the risks and benefits of oral contraceptives, and the shift in brain metabolism that begins in perimenopause. Dr. Gottfried explains actionable tools for hormone and micronutrient testing, nutrition, stress management, and cardiometabolic screening that women can use at any age.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

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Timestamps

(00:00:00) Female Hormone Health

(00:00:24) Family History, Intergenerational Trauma; Endometriosis, Fibroids, PCOS

(00:01:31) Biomarkers by Decade; Teens & Cortisol; 20s & Sex Hormones

(00:03:35) Tool: Hormone Test Timing; Micronutrient Testing, Magnesium

(00:05:41) Sponsor: LMNT

(00:07:17) Tool: Smoothies, Greens Powders & Microbiome

(00:08:12) Nutrient Panels, Antioxidants, B Vitamins, Glutathione

(00:09:34) Constipation, Thyroid Dysfunction; Trauma & Female Physiology

(00:11:50) Tools: Reduce Perceived Stress, Meditation, Yoga, Breathwork

(00:13:30) Opportunities by Decade; Androgens & Testosterone Decline

(00:14:50) PCOS, Diagnostic Criteria, Hirsutism, Cardiometabolic Risk

(00:17:10) Insulin & Glucose; Tool: Continuous Glucose Monitors

(00:18:05) Democratizing Health Data

(00:18:52) Sponsor: AG1

(00:20:07) Longevity "Don’ts"; Chronic Cardio & Cortisol; Tool: Adaptive Exercise

(00:22:46) Oral Contraceptives, Benefits & Ovarian Cancer Risk

(00:24:27) Ovarian Cancer Symptoms, Bloating, CA-125

(00:25:51) Oral Contraceptive Risks, Progestins, Inflammation; SHBG & Testosterone

(00:29:08) Clitoral Shrinkage; Tools: Alternatives for Painful Periods

(00:30:14) Sponsor: Eight Sleep

(00:31:32) Menopause & Perimenopause; 30s Hormonal Baseline

(00:33:07) Female Brain, Cerebral Hypometabolism & Alzheimer’s Risk

(00:35:02) Slow Brain Energy, Hormone Therapy; Hot Flashes as Biomarkers

(00:36:54) Tool: Coronary Artery Calcium Score

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