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Essentials: How to Control Your Sense of Pain & Pleasure

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

In this Huberman Lab Essentials episode, I explore the sensations of pain and pleasure, explaining how they are sensed in the body and interpreted by the brain as well as methods to control their intensity.

I discuss both the hardwired mechanisms and subjective factors that shape an individual’s perception of pain and pleasure. I also explain why pain thresholds vary from person to person and discuss various treatments for pain management such as acupuncture and supplements. Finally, I explain the role of key neurochemicals like dopamine and serotonin in mediating our experience of pain and pleasure.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

AG1: https://drinkag1.com/huberman

LMNT: https://drinklmnt.com/huberman

Eight Sleep: https://eightsleep.com/huberman

Timestamps

00:00:00 Pain & Pleasure

00:00:39 Skin, Appetitive vs Aversive Behaviors 

00:02:10 Skin, Neurons & Brain

00:04:46 Brain Interpretation, Homunculus, Two-Point Discrimination Test

00:07:43 Pain & Pleasure, Subjective Interpretation

00:09:53 Sponsor: AG1 

00:11:30 Tool: Pain & Expectation

00:13:08 Pain Threshold 

00:14:46 Heat & Cold, Tool: Moving into Cold or Hot Environments

00:16:37 Subjective Pain, Psychosomatic, Fibromyalgia, Whole Body Pain, Acetyl-L-carnitine

00:20:54 Acupuncture, Electroacupuncture, Pain Management

00:23:44 Sponsors: LMNT & Eight Sleep

00:26:36 Red Heads & Pain Threshold, Endorphins

00:28:32 Improving Pain Threshold, Dopamine 

00:30:00 Pleasure, Dopamine, Serotonin; Depression, Anti-depressants

00:34:12 Pleasure & Pain Balance, Dopamine, Addiction

00:36:08 Recap & Key Takeaways

Disclaimer & Disclosures
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