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Genes & the Inheritance of Memories Across Generations | Dr. Oded Rechavi

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

In this episode, my guest is Oded Rechavi, Ph.D., professor of neurobiology at Tel Aviv University and expert in how genes are inherited, how experiences shape genes and remarkably, how some memories of experiences can be passed via genes to offspring. We discuss his research challenging long-held tenets of genetic inheritance and the relevance of those findings to understanding key biological and psychological processes including metabolism, stress and trauma. He describes the history of the scientific exploration of the “heritability of acquired traits” and how epigenetics and RNA biology can account for some of the passage of certain experience-based memories. He discusses the importance of model organisms in scientific research and describes his work on how stressors and memories can be passed through small RNA molecules to multiple generations of offspring in ways that meaningfully affect their behavior. Nature vs. nurture is a commonly debated theme; Dr. Rechavi’s work represents a fundamental shift in our understanding of that debate, as well as genetic inheritance, brain function and evolution.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/huberman
Supplements from Momentous
https://www.livemomentous.com/huberman
Timestamps
(00:00:00) Dr. Oded Rechavi
(00:02:25) Sponsor: LMNT
(00:06:04) DNA, RNA, Protein; Somatic vs. Germ Cells
(00:14:36) Lamarckian Evolution, Inheritance of Acquired Traits
(00:22:54) Paul Kammerer & Toad Morphology
(00:25:16) Sponsor: AG1
(00:30:06) James McConnell & Memory Transfer
(00:37:31) Weismann Barrier; Epigenetics 
(00:45:13) Epigenetic Reprogramming; Imprinted Genes 
(00:50:43) Nature vs. Nurture; Epigenetics & Offspring
(00:59:06) Generational Epigenetic Inheritance 
(01:10:20) Model Organisms, C. elegans
(01:21:50) C. elegans & Inheritance of Acquired Traits, Small RNAs
(01:26:02) RNA Interference, C. elegans & Virus Immunity
(01:34:13) RNA Amplification, Multi-Generational Effects
(01:38:41) Response Duration & Environment
(01:47:50) Generational Memory Transmission, RNA
(01:59:36) Germ Cells & Behavior; Body Cues
(02:04:48) Transmission of Sexual Choice
(02:11:22) Fertility & Human Disease; 3-Parent In Vitro Fertilization (IVF); RNA Testing
(02:17:56) Deliberate Cold Exposure, Learning & Memory
(02:29:26) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac
Disclaimer

In this episode, my guest is Oded Rechavi, Ph.D., professor of neurobiology at Tel Aviv University and expert in how genes are inherited, how experiences shape genes and remarkably, how some memories of experiences can be passed via genes to offspring. We discuss his research challenging long-held tenets of genetic inheritance and the relevance of those findings to understanding key biological and psychological processes including metabolism, stress and trauma. He describes the history of the scientific exploration of the “heritability of acquired traits” and how epigenetics and RNA biology can account for some of the passage of certain experience-based memories. He discusses the importance of model organisms in scientific research and describes his work on how stressors and memories can be passed through small RNA molecules to multiple generations of offspring in ways that meaningfully affect their behavior. Nature vs. nurture is a commonly debated theme; Dr. Rechavi’s work represents a fundamental shift in our understanding of that debate, as well as genetic inheritance, brain function and evolution.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/hubermanlab
Waking Up: https://wakingup.com/huberman
Momentous: https://livemomentous.com/huberman
Timestamps
(00:00:00) Dr. Oded Rechavi
(00:02:25) Sponsor: LMNT
(00:06:04) DNA, RNA, Protein; Somatic vs. Germ Cells
(00:14:36) Lamarckian Evolution, Inheritance of Acquired Traits
(00:22:54) Paul Kammerer & Toad Morphology
(00:25:16) Sponsor: AG1
(00:30:06) James McConnell & Memory Transfer
(00:37:31) Weismann Barrier; Epigenetics 
(00:45:13) Epigenetic Reprogramming; Imprinted Genes 
(00:50:43) Nature vs. Nurture; Epigenetics & Offspring
(00:59:06) Generational Epigenetic Inheritance 
(01:10:20) Model Organisms, C. elegans
(01:21:50) C. elegans & Inheritance of Acquired Traits, Small RNAs
(01:26:02) RNA Interference, C. elegans & Virus Immunity
(01:34:13) RNA Amplification, Multi-Generational Effects
(01:38:41) Response Duration & Environment
(01:47:50) Generational Memory Transmission, RNA
(01:59:36) Germ Cells & Behavior; Body Cues
(02:04:48) Transmission of Sexual Choice
(02:11:22) Fertility & Human Disease; 3-Parent In Vitro Fertilization (IVF); RNA Testing
(02:17:56) Deliberate Cold Exposure, Learning & Memory
(02:29:26) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter
Disclaimer
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