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Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan Williams

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

In this episode, my guest is Nolan Williams, M.D., a triple board-certified psychiatrist, neurologist and professor of psychiatry and behavioral sciences at Stanford School of Medicine. He is also the Director of the Stanford Brain Stimulation Lab. We discuss clinical applications for brain stimulation, behavioral protocols and novel drug treatments to halt and reverse mental health disorders, including depression and post-traumatic stress disorder (PTSD). We first discuss the neural circuits for self-identity and mood and stress control. We discuss Dr. Williams’ work using transcranial magnetic stimulation (TMS) to depression, trauma, PTSD, and other mood disorders. We then dive deep into the history, biology, modern use, and safety margins of the various psychedelics, including MDMA, LSD, ketamine, ibogaine, ayahuasca, and psilocybin, as well as cannabis and the use of SSRIs in both adults and children. Finally, we discuss behavioral treatments for mental health disorders, including sleep and sleep deprivation, light exposure, exercise, and training to control the brain-heart-rate pathways. Regardless of age, all those interested in mental health should benefit from the incredible breadth and depth of Dr. Williams’ knowledge and the clarity with which he conveys that information.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1 (Athletic Greens): https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/huberman
Supplements from Momentous
https://www.livemomentous.com/huberman
Timestamps
(00:00:00) Dr. Nolan Williams, Brain Stimulation & Depression Treatment
(00:03:48) Sponsors: LMNT
(00:09:16) Depression, Risk Factors, Emergency Psychiatric Treatments
(00:15:11) The Brain-Heart Connection, Vagus Nerve, Prefrontal Cortex
(00:17:51) Right vs. Left Brain Hemispheres & Mood Balance, Connectome
(00:22:34) Heart Rate & Depression, Behavioral Interventions, Transcranial Magnetic Stimulation (TMS)
(00:33:02) Prefrontal Cortex & Cognitive Control, TMS
(00:35:30) Sponsor: AG1
(00:39:00) Belief/Identity “Rules”, Re-scripting, TMS & Talk Therapy
(00:45:49) Dorsolateral Prefrontal Cortex, TMS & Depression Treatment
(00:48:36) Cingulate Cortex & Emotion, Dissociation & Catatonia
(00:54:27) Ketamine, the Opioid System & Depression; Psychedelic Experience or Biology?
(01:03:42) SSRIs, Serotonin & Depression; Childhood, Chemical Imbalance or Circuit?
(01:13:58) Memories & “Rule” Creation; Psilocybin & “Rule” Resolution
(01:21:00) MDMA & Post-Traumatic Stress Disorder (PTSD) Treatment, Psilocybin & Depression Treatment
(01:24:12) Is MDMA Neurotoxic?, Drug Purity, Dopamine Surges, Post-MDMA Prolactin
(01:30:38) Psilocybin, Brain Connectivity & Depression Treatment
(01:34:53) Exposure Response Prevention: “Letting Go” & Depression Treatment
(01:41:23) Normal Spectrums for Mental Health Disorders
(01:45:35) Ibogaine & “Life Review”; PTSD, Depression & Clinical Trials
(01:57:16) Clinical Use of Psychedelics
(02:01:59) Ayahuasca, Brazilian Prisoner Study
(02:06:55) Cannabis: THC, CBD & Psychosis, Clinical Uses
(02:14:52) Personal Relative Drug Risk & Alcohol
(02:20:42) Circadian Reset for Depression, Sleep Deprivation, Light
(02:28:43) Stanford Neuromodulation Therapy (SNT) Study
(02:34:25) Space Learning Theory & TMS Stimulation
(02:45:35) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Huberman Lab Premium, Neural Network Newsletter, Social Media
Title Card Photo Credit: Mike Blabac
Disclaimer

In this episode, my guest is Nolan Williams, M.D., a triple board-certified psychiatrist, neurologist and professor of psychiatry and behavioral sciences at Stanford School of Medicine. He is also the Director of the Stanford Brain Stimulation Lab. We discuss clinical applications for brain stimulation, behavioral protocols and novel drug treatments to halt and reverse mental health disorders, including depression and post-traumatic stress disorder (PTSD). We first discuss the neural circuits for self-identity and mood and stress control. We discuss Dr. Williams’ work using transcranial magnetic stimulation (TMS) to depression, trauma, PTSD, and other mood disorders. We then dive deep into the history, biology, modern use, and safety margins of the various psychedelics, including MDMA, LSD, ketamine, ibogaine, ayahuasca, and psilocybin, as well as cannabis and the use of SSRIs in both adults and children. Finally, we discuss behavioral treatments for mental health disorders, including sleep and sleep deprivation, light exposure, exercise, and training to control the brain-heart-rate pathways. Regardless of age, all those interested in mental health should benefit from the incredible breadth and depth of Dr. Williams’ knowledge and the clarity with which he conveys that information.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/hubermanlab
Waking Up: https://wakingup.com/huberman
Momentous: https://livemomentous.com/huberman
Timestamps
(00:00:00) Dr. Nolan Williams, Brain Stimulation & Depression Treatment
(00:03:48) Sponsors: LMNT
(00:09:16) Depression, Risk Factors, Emergency Psychiatric Treatments
(00:15:11) The Brain-Heart Connection, Vagus Nerve, Prefrontal Cortex
(00:17:51) Right vs. Left Brain Hemispheres & Mood Balance, Connectome
(00:22:34) Heart Rate & Depression, Behavioral Interventions, Transcranial Magnetic Stimulation (TMS)
(00:33:02) Prefrontal Cortex & Cognitive Control, TMS
(00:35:30) Sponsor: AG1
(00:39:00) Belief/Identity “Rules”, Re-scripting, TMS & Talk Therapy
(00:45:49) Dorsolateral Prefrontal Cortex, TMS & Depression Treatment
(00:48:36) Cingulate Cortex & Emotion, Dissociation & Catatonia
(00:54:27) Ketamine, the Opioid System & Depression; Psychedelic Experience or Biology?
(01:03:42) SSRIs, Serotonin & Depression; Childhood, Chemical Imbalance or Circuit?
(01:13:58) Memories & “Rule” Creation; Psilocybin & “Rule” Resolution
(01:21:00) MDMA & Post-Traumatic Stress Disorder (PTSD) Treatment, Psilocybin & Depression Treatment
(01:24:12) Is MDMA Neurotoxic?, Drug Purity, Dopamine Surges, Post-MDMA Prolactin
(01:30:38) Psilocybin, Brain Connectivity & Depression Treatment
(01:34:53) Exposure Response Prevention: “Letting Go” & Depression Treatment
(01:41:23) Normal Spectrums for Mental Health Disorders
(01:45:35) Ibogaine & “Life Review”; PTSD, Depression & Clinical Trials
(01:57:16) Clinical Use of Psychedelics
(02:01:59) Ayahuasca, Brazilian Prisoner Study
(02:06:55) Cannabis: THC, CBD & Psychosis, Clinical Uses
(02:14:52) Personal Relative Drug Risk & Alcohol
(02:20:42) Circadian Reset for Depression, Sleep Deprivation, Light
(02:28:43) Stanford Neuromodulation Therapy (SNT) Study
(02:34:25) Space Learning Theory & TMS Stimulation
(02:45:35) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Huberman Lab Premium, Neural Network Newsletter, Social Media
Disclaimer
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