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Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

This episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We discuss the biology and medical clinical-trial uses of psilocybin, MDMA, ayahuasca, DMT, and LSD. Dr. Johnson teaches us what the clinical trials in his lab are revealing about the potential these compounds hold for the treatment of depression, addiction, trauma, eating disorders, ADHD, and other disorders of the mind. Dr. Johnson describes a typical psychedelic experiment in his laboratory, start to finish, including the conditions for optimal clinical outcomes. And he explains some of the potential hazards and common misconceptions and pitfalls related to psychedelic medicine. Dr. Johnson explains flashbacks, the heightened risks of certain people and age groups using psychedelics and the ever evolving legal and pharmaceutical industry landscape surrounding psychedelics. Dr. Johnson also explains how the scientific study of psychedelics is likely to set the trajectory of psychiatric medicine in the years to come. Dr. Johnson is among a small handful of researchers who have pioneered the clinical study of these powerful compounds. He has unprecedented insight into how they can be woven into other psychiatric treatments, changing ones sense of self and of reality.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1 (Athletic Greens): https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/huberman
Supplements from Momentous
https://www.livemomentous.com/huberman
Timestamps
(00:00:00) Introducing Dr. Matthew Johnson
(00:02:27) Sponsors: AG1, LMNT
(00:06:40) ‘Psychedelics’ Defined
(00:14:09) Hallucinations, Synesthesia, Altered Space-Time Perception
(00:19:56) Serotonin & Dopamine 
(00:23:50) Ketamine & Glutamate 
(00:28:00) An Example Psychedelic Experiment
(00:37:30) ‘Letting Go’ with Psychedelics
(00:44:10) Our Mind’s Eye
(00:48:00) Redefining Your Sense of Self 
(00:58:56) Exporting Psychedelic Learnings to Daily Life
(01:04:36) Flashbacks
(01:12:10) Ayahuasca, & ASMR, Kundalini Breathing
(01:15:54) MDMA, DMT
(01:26:00) Dangers of Psychedelics, Bad Trips, Long-Lasting Psychosis
(01:38:15) Micro-Dosing
(01:56:45) Risks for Kids, Adolescents & Teenagers; Future Clinical Trials
(02:03:40) Legal Status: Decriminalization vs. Legalization vs. Regulation
(02:18:35) Psychedelics for Treating Concussion & Traumatic Brain Injury 
(02:27:45) Shifting Trends in Psychedelic Research, Academic Culture
(02:44:23) Participating in a Clinical Trial, Online Survey Studies, Breathwork 
(02:50:38) Conclusions, Subscribing & Supporting the HLP, Supplements
Title Card Photo Credit: Mike Blabac
Disclaimer

This episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Ph.D., Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We discuss the biology and medical clinical-trial uses of psilocybin, MDMA, ayahuasca, DMT, and LSD. Dr. Johnson teaches us what the clinical trials in his lab are revealing about the potential these compounds hold for the treatment of depression, addiction, trauma, eating disorders, ADHD, and other disorders of the mind. Dr. Johnson describes a typical psychedelic experiment in his laboratory, start to finish, including the conditions for optimal clinical outcomes. And he explains some of the potential hazards and common misconceptions and pitfalls related to psychedelic medicine. Dr. Johnson explains flashbacks, the heightened risks of certain people and age groups using psychedelics and the ever evolving legal and pharmaceutical industry landscape surrounding psychedelics. Dr. Johnson also explains how the scientific study of psychedelics is likely to set the trajectory of psychiatric medicine in the years to come. Dr. Johnson is among a small handful of researchers who have pioneered the clinical study of these powerful compounds. He has unprecedented insight into how they can be woven into other psychiatric treatments, changing ones sense of self and of reality.
Read the full show notes for this episode at hubermanlab.com.
Thank you to our sponsors
AG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/hubermanlab
Waking Up: https://wakingup.com/huberman
Momentous: https://livemomentous.com/huberman
Timestamps
00:00:00 Introducing Dr. Matthew Johnson  
00:02:27 Sponsors: AG1, LMNT & Waking Up
00:06:40 ‘Psychedelics’ Defined  
00:14:09 Hallucinations, Synesthesia, Altered Space-Time Perception  
00:19:56 Serotonin & Dopamine  
00:23:50 Ketamine & Glutamate  
00:28:00 An Example Psychedelic Experiment  
00:37:30 ‘Letting Go’ with Psychedelics  
00:44:10 Our Mind’s Eye  
00:48:00 Redefining Your Sense of Self  
00:58:56 Exporting Psychedelic Learnings to Daily Life  
01:04:36 Flashbacks  
01:12:10 Ayahuasca, ASMR, Kundalini Breathing  
01:15:54 MDMA, DMT  
01:26:00 Dangers of Psychedelics, Bad Trips, Long-Lasting Psychosis  
01:38:15 Micro-Dosing  
01:56:45 Risks for Kids, Adolescents & Teenagers; Future Clinical Trials  
02:03:40 Legal Status: Decriminalization vs. Legalization vs. Regulation  
02:18:35 Psychedelics for Treating Concussion & Traumatic Brain Injury  
02:27:45 Shifting Trends in Psychedelic Research, Academic Culture  
02:44:23 Participating in a Clinical Trial, Online Survey Studies, Breathwork  
02:50:38 Conclusions, Subscribing & Supporting the HLP, Supplements  
Disclaimer & Disclosures
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