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How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

Huberman Lab

The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017. 
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.

My guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health and well-being in both men and women. We discuss how to improve hormones using behavioral, nutritional, and exercise-based tools and safely and rationally approach supplementation and hormone therapies. We discuss testosterone and estrogen and how those hormones relate to fertility, mood, aging, relationships, disease pathologies, thyroid hormone, growth hormone, prolactin, dopamine and peptides that impact physical and mental health and vitality across the lifespan. The episode is rich with scientific mechanisms and tools for people to consider.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1 (Athletic Greens): https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/huberman
Supplements from Momentous
https://www.livemomentous.com/huberman
Timestamps
(00:00:00) Dr. Kyle Gillett, MD, Hormone Optimization   
(00:03:28) Sponsors: AG1, LMNT
(00:08:24) Preventative Medicine & Hormone Health 
(00:14:17) The Six Pillars of Hormone Health Optimization
(00:17:14) Diet for Hormone Health, Blood Testing
(00:20:21) Exercise for Hormone Health 
(00:21:06) Caloric Restriction, Obesity & Testosterone 
(00:23:55) Intermittent Fasting, Growth Hormone (GH), IGF-1
(00:29:08) Sleep Quality & Hormones
(00:35:03) Testosterone in Women
(00:38:55) Dihydrotestosterone (DHT), Hair Loss 
(00:43:46) DHT in Men and Women, Turmeric/Curcumin, Creatine
(00:50:10) 5-Alpha Reductase, Finasteride, Saw Palmetto 
(00:52:30) Hair loss, DHT, Creatine Monohydrate
(00:55:07) Hair Regrowth, Male Pattern Baldness
(00:58:12) Polycystic Ovary Syndrome (PCOS), Inositol, DIM
(01:04:00) Oral Contraception, Perceived Attractiveness, Fertility 
(01:10:31) Testosterone & Marijuana or Alcohol
(01:14:27) Sleep Supplement Frequency
(01:15:34) Testosterone Supplementation & Prostate Cancer 
(01:20:24) Prostate Health, Dietary Fiber, Saw Palmetto, C-Reactive Protein  
(01:24:05) Prostate Health & Pelvic Floor, Viagra, Tadalafil 
(01:30:54) Testosterone Replacement Therapy (TRT)
(01:35:17) Estrogen & Aromatase Inhibitors, Calcium D-Glucarate, DIM 
(01:39:28) Lifestyle Factors to Increase Testosterone/Estrogen Levels, Dietary Fats 
(01:45:34) Aromatase Supplements: Ecdysterone, Turkesterone
(01:47:04) Tongkat Ali (Long Jack), Estrogen/Testosterone levels 
(01:52:25) Fadogia Agrestis, Luteinizing Hormone (LH), Frequency
(01:56:44) Boron, Sex Hormone Binding Globulin (SHBG)
(01:58:13) Human Chorionic Gonadotropin (hCG), Fertility
(02:04:18) Prolactin & Dopamine, Pituitary Damage 
(02:08:34) Augmenting Dopamine Levels: Casein, Gluten, Vitamin E, Vitamin B6 (P5P)
(02:12:30) L-Carnitine & Fertility, TMAO & Allicin (Garlic) 
(02:18:19) Blood Test Frequency 
(02:19:41) Long-Term Relationships & Effects on Hormones
(02:25:33) Nesting Instincts: Prolactin, Childbirth & Relationships
(02:29:05) Cold & Hot Exposure, Hormones & Fertility
(02:32:34) Peptide Hormones: Insulin, Tesamorelin, Ghrelin 
(02:37:24) Growth Hormone-Releasing Peptides (GHRPs)
(02:39:38) BPC-157 & Injury, Dosing Frequency
(02:45:23) Uses for Melanotan 
(02:48:21) Spiritual Health Impact on Mental & Physical Health 
(02:54:18) Caffeine & Hormones 
(02:56:19) Neural Network Newsletter, Zero-Cost Support, YouTube Feedback, Spotify Review, Apple Reviews, Sponsors, Supplements, Instagram, Twitter
Title Card Photo Credit: Mike Blabac
Disclaimer

My guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health and well-being in both men and women. We discuss how to improve hormones using behavioral, nutritional, and exercise-based tools and safely and rationally approach supplementation and hormone therapies. We discuss testosterone and estrogen and how those hormones relate to fertility, mood, aging, relationships, disease pathologies, thyroid hormone, growth hormone, prolactin, dopamine and peptides that impact physical and mental health and vitality across the lifespan. The episode is rich with scientific mechanisms and tools for people to consider.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/hubermanlab
Waking Up: https://wakingup.com/huberman
Momentous: https://livemomentous.com/huberman
Timestamps
(00:00:00) Dr. Kyle Gillett, MD, Hormone Optimization   
(00:03:28) Sponsors: AG1, LMNT
(00:08:24) Preventative Medicine & Hormone Health 
(00:14:17) The Six Pillars of Hormone Health Optimization
(00:17:14) Diet for Hormone Health, Blood Testing
(00:20:21) Exercise for Hormone Health 
(00:21:06) Caloric Restriction, Obesity & Testosterone 
(00:23:55) Intermittent Fasting, Growth Hormone (GH), IGF-1
(00:29:08) Sleep Quality & Hormones
(00:35:03) Testosterone in Women
(00:38:55) Dihydrotestosterone (DHT), Hair Loss 
(00:43:46) DHT in Men and Women, Turmeric/Curcumin, Creatine
(00:50:10) 5-Alpha Reductase, Finasteride, Saw Palmetto 
(00:52:30) Hair loss, DHT, Creatine Monohydrate
(00:55:07) Hair Regrowth, Male Pattern Baldness
(00:58:12) Polycystic Ovary Syndrome (PCOS), Inositol, DIM
(01:04:00) Oral Contraception, Perceived Attractiveness, Fertility 
(01:10:31) Testosterone & Marijuana or Alcohol
(01:14:27) Sleep Supplement Frequency
(01:15:34) Testosterone Supplementation & Prostate Cancer 
(01:20:24) Prostate Health, Dietary Fiber, Saw Palmetto, C-Reactive Protein  
(01:24:05) Prostate Health & Pelvic Floor, Viagra, Tadalafil 
(01:30:54) Testosterone Replacement Therapy (TRT)
(01:35:17) Estrogen & Aromatase Inhibitors, Calcium D-Glucarate, DIM 
(01:39:28) Lifestyle Factors to Increase Testosterone/Estrogen Levels, Dietary Fats 
(01:45:34) Aromatase Supplements: Ecdysterone, Turkesterone
(01:47:04) Tongkat Ali (Long Jack), Estrogen/Testosterone levels 
(01:52:25) Fadogia Agrestis, Luteinizing Hormone (LH), Frequency
(01:56:44) Boron, Sex Hormone Binding Globulin (SHBG)
(01:58:13) Human Chorionic Gonadotropin (hCG), Fertility
(02:04:18) Prolactin & Dopamine, Pituitary Damage 
(02:08:34) Augmenting Dopamine Levels: Casein, Gluten, Vitamin E, Vitamin B6 (P5P)
(02:12:30) L-Carnitine & Fertility, TMAO & Allicin (Garlic) 
(02:18:19) Blood Test Frequency 
(02:19:41) Long-Term Relationships & Effects on Hormones
(02:25:33) Nesting Instincts: Prolactin, Childbirth & Relationships
(02:29:05) Cold & Hot Exposure, Hormones & Fertility
(02:32:34) Peptide Hormones: Insulin, Tesamorelin, Ghrelin 
(02:37:24) Growth Hormone-Releasing Peptides (GHRPs)
(02:39:38) BPC-157 & Injury, Dosing Frequency
(02:45:23) Uses for Melanotan 
(02:48:21) Spiritual Health Impact on Mental & Physical Health 
(02:54:18) Caffeine & Hormones 
(02:56:19) Neural Network Newsletter, Zero-Cost Support, YouTube Feedback, Spotify Review, Apple Reviews, Sponsors, Supplements, Instagram, Twitter
Disclaimer
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