Avoiding, Treating & Curing Cancer With the Immune System | Dr. Alex Marson
Dr. Alex Marson, MD, PhD, is a professor of medicine at the University of California, San Francisco. We discuss the biology of the immune system and cancer, and everyday choices that can increase or decrease your cancer risk, several of which are surprising but all of which are actionable. We also discuss immunotherapy, including how engineered T-cells can be used to defeat childhood and adult cancers. Dr. Marson explains CRISPR and gene editing to cure diseases, and we address the ethical questions surrounding gene editing in embryos, children and adults. This discussion is for anyone interested in avoiding cancer and/or seeking to understand the science and practical applications of immune- or gene-therapy.
Read the show notes at hubermanlab.com.
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Timestamps
(00:00:00) Alex Marson
(00:02:21) Diseases & Current Biological Landscape; AI & Computational Tools
(00:05:56) Immune System, Innate vs Adaptive Immune System
(00:10:55) Thymus, T Cell Selection; B Cells & Antibodies
(00:13:23) Sponsors: BetterHelp & Helix Sleep
(00:16:11) Immune System Health, Sleep, Diet; Genes
(00:20:56) Childhood Exposure & Allergy Prevention; Autoimmune Reactions
(00:25:27) Whole Body Immune Response, Cytokines & Fever; Antibiotics
(00:30:51) Cancer; Mutations & Cell Regulation; Smoking, BRCA Mutations, Sunlight
(00:38:27) BRAC Mutations, Mutagens, Pesticides
(00:42:33) Sponsor: AG1
(00:43:57) X-Rays & Airport Scanners, Carcinogen vs Mutagen, Charred Meat, Food Dye
(00:49:34) Immune-Based Cancer Treatment, Checkpoint Inhibitors, CAR T-Cell Therapy
(00:59:04) CRISPR, Immunotherapies
(01:02:52) Age & Cancer Risk; CAR T-Cells, Targets & Side Effects; Ketogenic Diet
(01:08:27) CRISPR Discovery & Mechanism
(01:17:06) CRISPR Precision, Risk & Benefit; CRISPR Technology Evolution
(01:20:57) Sponsor: LMNT
(01:22:17) CRISPR Cell Delivery, Clinical Trials; Treating Early Cancers & Prevention
(01:33:47) Liposomes, Engineered Viruses, Lipid Nanoparticles (LNPs), Vaccines
(01:39:57) COVID Pandemic & Trust in Science, mRNA Vaccine
(01:47:51) Sponsor: Function
(01:49:39) Drug Delivery to Cancer, Immunotoxins, T-Cell Engagers; AI Protein Targets
(01:55:45) CRISPR Embryo Modification, Ethics; Heritable Gene Editing, Diversity
(02:05:42) Deep Sequencing Embryos, Diversity; Overcoming Adversity & Resilience
(02:10:44) Upcoming Therapeutics, Autoimmunity & CAR T-Cells, CRISPR & Gene Function
(02:17:55) Banking T Cells or iPSCs?, Future of Cell Programming
(02:24:41) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
Disclaimer & Disclosures
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Popis podcastu
The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.
Huberman has made numerous significant contributions to the fields of brain development, brain function, and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills, and cognitive functioning. He is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award, given to the scientist making the most significant discoveries in the study of vision, in 2017.
Work from the Huberman Laboratory at Stanford School of Medicine has been published in top journals, including Nature, Science, and Cell, and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.
In 2021, Dr. Huberman launched the Huberman Lab podcast. The podcast is frequently ranked in the top 10 of all podcasts globally and is often ranked #1 in the categories of Science, Education, and Health & Fitness.