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#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)

The Tim Ferriss Show

Tim Ferriss is a self-experimenter and bestselling author, best known for The 4-Hour Workweek, which has been translated into 40+ languages. Newsweek calls him "the world's best human guinea pig," and The New York Times calls him "a cross between Jack Welch and a Buddhist monk." In this show, he deconstructs world-class performers from eclectic areas (investing, chess, pro sports, etc.), digging deep to find the tools, tactics, and tricks that listeners can use.

Dr. Dominic D’Agostino (<a href="https://x.com/DominicDAgosti2" rel="noopener noreferrer" target="_blank">@DominicDAgosti2</a>) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.This episode is brought to you by:<ul><li><a href="https://gusto.com/tim" rel="noopener noreferrer" target="_blank">Gusto</a> simple and easy payroll, HR, and benefits platform used by 400,000+ businesses: <a href="https://gusto.com/tim" rel="noopener noreferrer" target="_blank">https://gusto.com/tim</a> </li><li><a href="https://seed.com/tim" rel="noopener noreferrer" target="_blank">Seed's DS-01® Daily Synbiotic</a> broad spectrum 24-strain probiotic + prebiotic: <a href="https://seed.com/tim" rel="noopener noreferrer" target="_blank">https://Seed.com/Tim</a> </li><li><a href="https://davidprotein.com/pages/tim" rel="noopener noreferrer" target="_blank">David Protein Bars</a> 28g of protein, 150 calories, and 0g of sugar: <a href="https://davidprotein.com/tim" rel="noopener noreferrer" target="_blank">https://davidprotein.com/tim</a> </li><li><a href="http://coyotegame.com/" rel="noopener noreferrer" target="_blank">Coyote the card game​</a>, which I co-created with Exploding Kittens: <a href="https://coyotegame.com/" rel="noopener noreferrer" target="_blank">https://coyotegame.com</a></li></ul>*For show notes and past guests on <a href="https://tim.blog/podcast" rel="noopener noreferrer" target="_blank">The Tim Ferriss Show</a>, please visit <a href="https://tim.blog/podcast/?utm_source=podcast&utm_medium=podcast&utm_campaign=podcast-description" rel="noopener noreferrer" target="_blank">tim.blog/podcast</a>.For deals from sponsors of <a href="https://tim.blog/podcast" rel="noopener noreferrer" target="_blank">The Tim Ferriss Show</a>, please visit <a href="https://tim.blog/podcast-sponsors" rel="noopener noreferrer" target="_blank">tim.blog/podcast-sponsors</a>Sign up for Tim’s email newsletter (5-Bullet Friday) at <a href="https://go.tim.blog/5-bullet-friday-1/" rel="noopener noreferrer" target="_blank">tim.blog/friday</a>.For transcripts of episodes, go to <a href="https://tim.blog/transcripts" rel="noopener noreferrer" target="_blank">tim.blog/transcripts</a>.Discover Tim’s books: <a href="https://tim.blog/books" rel="noopener noreferrer" target="_blank">tim.blog/books</a>.Follow Tim:Twitter: <a href="https://twitter.com/tferriss" rel="noopener noreferrer" target="_blank">twitter.com/tferriss</a> Instagram: <a href="https://instagram.com/timferriss/" rel="noopener noreferrer" target="_blank">instagram.com/timferriss</a>YouTube: <a href="https://www.youtube.com/timferriss" rel="noopener noreferrer" target="_blank">youtube.com/timferriss</a>Facebook: <a href="https://www.facebook.com/TimFerriss/" rel="noopener noreferrer" target="_blank">facebook.com/timferriss</a> LinkedIn: <a href="http://linkedin.com/in/timferriss" rel="noopener noreferrer" target="_blank">linkedin.com/in/timferriss</a>See Privacy Policy at <a href="https://art19.com/privacy" rel="noopener noreferrer" target="_blank">https://art19.com/privacy</a> and California Privacy Notice at <a href="https://art19.com/privacy#do-not-sell-my-info" rel="noopener noreferrer" target="_blank">https://art19.com/privacy#do-not-sell-my-info</a>.

Dr. Dominic D’Agostino (<a href="https://x.com/DominicDAgosti2" rel="noopener noreferrer" target="_blank">@DominicDAgosti2</a>) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.This episode is brought to you by:<ul><li><a href="https://gusto.com/tim" rel="noopener noreferrer" target="_blank">Gusto</a> simple and easy payroll, HR, and benefits platform used by 400,000+ businesses: <a href="https://gusto.com/tim" rel="noopener noreferrer" target="_blank">https://gusto.com/tim</a> </li><li><a href="https://seed.com/tim" rel="noopener noreferrer" target="_blank">Seed's DS-01® Daily Synbiotic</a> broad spectrum 24-strain probiotic + prebiotic: <a href="https://seed.com/tim" rel="noopener noreferrer" target="_blank">https://Seed.com/Tim</a> </li><li><a href="https://davidprotein.com/pages/tim" rel="noopener noreferrer" target="_blank">David Protein Bars</a> 28g of protein, 150 calories, and 0g of sugar: <a href="https://davidprotein.com/tim" rel="noopener noreferrer" target="_blank">https://davidprotein.com/tim</a> </li><li><a href="http://coyotegame.com/" rel="noopener noreferrer" target="_blank">Coyote the card game​</a>, which I co-created with Exploding Kittens: <a href="https://coyotegame.com/" rel="noopener noreferrer" target="_blank">https://coyotegame.com</a></li></ul>*Timestamps:<ul><li>[00:00:00] Who is Dominic D'Agostino? </li><li>[00:04:37] Ketosis benefits: Quieting the mind, GABA elevation, metabolic psychiatry.</li><li>[00:09:24] My Lyme disease story: Pseudo-dementia reversed in 3-4 days of ketosis.</li><li>[00:13:50] Spirochetes are glycolytic: Starve the bug, boost the immune response.</li><li>[00:19:20] Ketosis and cancer: Slowing glycolytic tumors, enhancing standard care.</li><li>[00:20:50] My 18-day keto experiment: Mood stabilization, Alzheimer’s prevention hopes.</li><li>[00:23:19] Metabolic memory: Carryover effects and Valter Longo’s fasting mimicking research.</li><li>[00:27:11] Intermittent fasting as keto on-ramp: My 2-8 p.m. eating window.</li><li>[00:29:15] Dom’s budget keto meal: Canned mackerel, MCT oil, apple cider vinegar.</li><li>[00:33:28] My ketone measurement paradox: Feeling sharp at 0.2 mM readings.</li><li>[00:36:56] The carburetor analogy: Ketone production vs. utilization explained.</li><li>[00:38:43] Breath ketones vs. blood ketones: Better indicator in caloric deficit.</li><li>[00:39:47] Gluconeogenesis fears: Fat, fiber, and salt to slow protein absorption.</li><li>[00:45:25] The bunless double cheeseburger question: 80 grams of protein in one sitting.</li><li>[00:49:03] Post-meal walking and GLUT4 activation: Timing your glucose disposal.</li><li>[00:51:02] CGM and ketone monitor limitations: When your devices gaslight you.</li><li>[00:58:05] Rabbit starvation and protein-veggie days: Why your body won’t bankroll its own ketosis.</li><li>[01:05:44] Alzheimer’s prevention: Biomarkers, B12, hsCRP, and metabolic health.</li><li>[01:09:40] My family history: Letrozole, metabolic dysfunction, and rapid cognitive decline.</li><li>[01:13:17] Minimum effective dose: 80% of benefits from low-carb Mediterranean.</li><li>[01:18:56] One week per month protocol: Aggressive calorie cut to ramp ketones.</li><li>[01:23:12] GKI sweet spot: Target 1-4, aim for 1-2 during intensive weeks.</li><li>[01:36:22] Exogenous ketones 101: Palatability, tolerability, pharmacokinetics, toxicity.</li><li>[01:39:21] 1,3-Butanediol warnings: Liver toxicity, NAD depletion, dependency risk.</li><li>[01:54:22] Intermittent fasting vs. ketogenic breakfast.</li><li>[01:59:09] My accidental intoxication story.</li><li>[02:03:23] Dr. Veech tribute: Student of Hans Krebs, ketone ester pioneer.</li><li>[02:05:08] Fiber on keto: Wild blueberries, broccoli, apples, walnuts.</li><li>[02:09:58] The tainted gummies incident: Dom’s forensic investigation underway.</li><li>[02:13:08] Thanks to Dr. Boz and Medifoodz.</li><li>[02:16:19] Parting thoughts.</li></ul> For show notes and past guests on <a href="https://tim.blog/podcast" rel="noopener noreferrer" target="_blank">The Tim Ferriss Show</a>, please visit <a href="https://tim.blog/podcast/?utm_source=podcast&utm_medium=podcast&utm_campaign=podcast-description" rel="noopener noreferrer" target="_blank">tim.blog/podcast</a>.For deals from sponsors of <a href="https://tim.blog/podcast" rel="noopener noreferrer" target="_blank">The Tim Ferriss Show</a>, please visit <a href="https://tim.blog/podcast-sponsors" rel="noopener noreferrer" target="_blank">tim.blog/podcast-sponsors</a>Sign up for Tim’s email newsletter (5-Bullet Friday) at <a href="https://go.tim.blog/5-bullet-friday-1/" rel="noopener noreferrer" target="_blank">tim.blog/friday</a>.For transcripts of episodes, go to <a href="https://tim.blog/transcripts" rel="noopener noreferrer" target="_blank">tim.blog/transcripts</a>.Discover Tim’s books: <a href="https://tim.blog/books" rel="noopener noreferrer" target="_blank">tim.blog/books</a>.Follow Tim:Twitter: <a href="https://twitter.com/tferriss" rel="noopener noreferrer" target="_blank">twitter.com/tferriss</a> Instagram: <a href="https://instagram.com/timferriss/" rel="noopener noreferrer" target="_blank">instagram.com/timferriss</a>YouTube: <a href="https://www.youtube.com/timferriss" rel="noopener noreferrer" target="_blank">youtube.com/timferriss</a>Facebook: <a href="https://www.facebook.com/TimFerriss/" rel="noopener noreferrer" target="_blank">facebook.com/timferriss</a> LinkedIn: <a href="http://linkedin.com/in/timferriss" rel="noopener noreferrer" target="_blank">linkedin.com/in/timferriss</a>See Privacy Policy at <a href="https://art19.com/privacy" rel="noopener noreferrer" target="_blank">https://art19.com/privacy</a> and California Privacy Notice at <a href="https://art19.com/privacy#do-not-sell-my-info" rel="noopener noreferrer" target="_blank">https://art19.com/privacy#do-not-sell-my-info</a>.

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#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)

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