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Intro

The Mission to Prevent Alzheimer's

When Does Dementia Actually Start?

The Top 5 Lifestyle Causes of Alzheimer's

Does the APOE4 Gene Mean You'll Get Alzheimer's?

How Exercise Can Cut Your Alzheimer's Risk

How Loneliness Raises Your Risk of Dementia

The Brain's Evil Twin Immune Cells Behind Alzheimer's

Is Alzheimer's the Brain Pruning Itself Like a Child's?

How Poor Sleep Damages Your Brain

How Inflammation Hijacks Your Decision-Making

How Much Sugar Is in Your Orange Juice?

What a Continuous Glucose Monitor Reveals About Your Diet

Gluten, Glyphosate and Your Brain

The Polyphenol-Rich Foods That Protect Your Brain

The Link Between Type 2 Diabetes, Alzheimer's and Parkinson's

Why Visceral Fat Is So Dangerous for Your Brain

Is Any Amount of Alcohol Safe for Your Brain?

Why Women Have Twice the Risk of Alzheimer's

Can 40Hz Light and Sound Help Treat Alzheimer's?

The Sugar Rationing Study That Cut Alzheimer's Risk by 40

How Your Gut Microbiome Affects Dementia Risk

Why Head Injuries Cause Lasting Brain Damage

Why Head Trauma Is Worse for Type 2 Diabetics

Should Healthy People Take Metformin?

The Letter Dr. Perlmutter Wrote at 15

How Becoming a Grandfather Changed Dr. Perlmutter

What Can People With Alzheimer's Do Right Now?

Can a Ketogenic Diet Help Treat Dementia?

The Supplements Dr. Perlmutter Takes for Brain Performance

What Is It Like to Have Alzheimer's?

A Letter From His Son Austin

Why Reconnecting Is the Key to a Healthy Brain

Top Neurologist: If You Drink Even Once A Week, Watch This Now!

The Diary Of A CEO with Steven Bartlett

Welcome to The Diary Of A CEO where you'll find raw, human conversations with the world’s most fascinating experts, storytellers, thinkers and business leaders.

Hosted by Steven Bartlett (entrepreneur, investor, author, and founder of Steven.com and Flight Fund) this channel was created with a simple mission: to share personal lessons that help both you live better, more fulfilling lives.

What is DOAC? Beyond Diary Of A CEO, the acronym reflects our core ethos:

- Dreamers — Dream boldly.
- Open-minded — Think without limits.
- Awareness — Expand your perspective.
- Connection — Feel more connected.

This is your corner of the internet to dream boldly, think openly, expand your awareness, and feel more connected.
The Diary Of A CEO:
◼ Join DOAC circle here - https://doaccircle.com/
◼ Buy The Diary Of A CEO book here - https://link.thediaryofaceo.com/BWjLTZK
◼ Shop The Diary Of A CEO collection: https://thediary.com/collections/shop
◼ Get email updates - https://link.thediaryofaceo.com/5IB1H6E
◼ Follow Steven - https://link.thediaryofaceo.com/AGU9QP4

What if the decline of your cognitive function isn't a genetic inevitability, but a metabolic choice you’re making every single day? Board-certified neurologist Dr. David Perlmutter discusses cognitive decay and outlines the definitive protocol for lifelong brain health and dementia prevention.

Dr. David Perlmutter is a pioneering researcher who radically challenged the medical establishment by linking metabolic dysfunction to severe neurodegenerative diseases. He is the author of several groundbreaking texts, including his most recent release, Brain Defenders. This project aims to empower individuals to regain agency over their longevity by harnessing the brain's immune system to reverse and prevent cognitive decline.

In this episode, he explains:
■ The Evil Twin Phenomenon: How high blood sugar and inflammation hijack your brain's protective microglial immune cells and shift them into a destructive state that actively devours healthy synapses.
■ The Power of Exercise: Why building muscle helps secrete protective chemicals to actively regenerate neurons and block cognitive decay.
■ The Oxytocin Shield: How deep social connections and community integration fundamentally alter your brain's inflammatory response and keep your neural immune system in a supportive state.
■ The Glymphatic Street Cleaners: Why missing out on stage four deep sleep immediately cripples your brain's ability to sweep out toxic amyloid-beta plaques overnight.
■ The 40Hz Reset: How specific frequencies of flashing light and sound can revert rogue brain cells back into protective guardians and restore your baseline neural rhythms.

https://stevenbartlett.com/wp-content/uploads/2026/11/Independent-Research-Perlmutter-DOAC-PhiloScript.pdf

Chapters

00:00:00 Intro
00:02:16 The Mission to Prevent Alzheimer's
00:07:36 When Does Dementia Actually Start?
00:11:57 The Top 5 Lifestyle Causes of Alzheimer's
00:13:53 Does the APOE4 Gene Mean You'll Get Alzheimer's?
00:16:27 How Exercise Can Cut Your Alzheimer's Risk
00:21:40 How Loneliness Raises Your Risk of Dementia
00:23:52 The Brain's Evil Twin Immune Cells Behind Alzheimer's
00:31:12 Is Alzheimer's the Brain Pruning Itself Like a Child's?
00:35:04 How Poor Sleep Damages Your Brain
00:38:22 How Inflammation Hijacks Your Decision-Making
00:41:34 How Much Sugar Is in Your Orange Juice?
00:44:54 What a Continuous Glucose Monitor Reveals About Your Diet
00:48:13 Gluten, Glyphosate and Your Brain
00:53:41 Ads
00:55:58 The Polyphenol-Rich Foods That Protect Your Brain
01:01:24 The Link Between Type 2 Diabetes, Alzheimer's and Parkinson's
01:03:08 Why Visceral Fat Is So Dangerous for Your Brain
01:05:13 Is Any Amount of Alcohol Safe for Your Brain?
01:08:15 Why Women Have Twice the Risk of Alzheimer's
01:10:25 Can 40Hz Light and Sound Help Treat Alzheimer's?
01:15:20 The Sugar Rationing Study That Cut Alzheimer's Risk by 40%
01:16:43 How Your Gut Microbiome Affects Dementia Risk
01:20:42 Why Head Injuries Cause Lasting Brain Damage
01:21:46 Ads
01:23:48 Why Head Trauma Is Worse for Type 2 Diabetics
01:25:07 Should Healthy People Take Metformin?
01:29:11 The Letter Dr. Perlmutter Wrote at 15
01:30:35 How Becoming a Grandfather Changed Dr. Perlmutter
01:33:37 What Can People With Alzheimer's Do Right Now?
01:36:38 Can a Ketogenic Diet Help Treat Dementia?
01:39:32 The Supplements Dr. Perlmutter Takes for Brain Performance
01:41:39 What Is It Like to Have Alzheimer's?
01:47:38 A Letter From His Son Austin
01:52:13 Why Reconnecting Is the Key to a Healthy Brain

Follow Dr. David Perlmutter:
Website - https://link.thediaryofaceo.com/DlFD0WV
Instagram - https://link.thediaryofaceo.com/2nGvKls
YouTube - https://link.thediaryofaceo.com/7MBF8NY

Dr. Perlmutter has a free resource for DOAC listeners, 10 questions to reveal how well your daily habits are protecting your brain’s future: 
The Brain Defenders Assessment - https://link.thediaryofaceo.com/ADzqL18

The Diary Of A CEO:
◼ Join DOAC circle here - https://doaccircle.com/
◼ Buy The Diary Of A CEO book here - https://link.thediaryofaceo.com/BWjLTZK
◼ Shop The Diary Of A CEO collection: https://thediary.com/collections/shop
◼ Get email updates - https://link.thediaryofaceo.com/5IB1H6E
◼ Follow Steven - https://link.thediaryofaceo.com/AGU9QP4
◼ DOAC Bookshelf - https://link.thediaryofaceo.com/BBnuCf6

Sponsors:
Pipedrive - https://pipedrive.com/CEO 
Grok Bot - Get 50% off your first month at https://x.ai.com/doac 
Linkedin Talent Solutions - http://linkedin.com/DOAC 
Cometeer - http://cometeer.com/steven use code STEVEN for $30 off

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Top Neurologist: If You Drink Even Once A Week, Watch This Now!

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