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How Alcohol Rewires Your Brain and Increases Cancer Risk by 40%! The Alcohol Doctor, Dr. Sarah Wakeman

The Diary Of A CEO with Steven Bartlett

Steven Bartlett is a British entrepreneur, investor, and author. He’s the founder of Flight Story – a media company – and Flight Fund, an investment fund backing the next generation of category-defining businesses.
He created The Diary Of A CEO to share the unfiltered pages of the personal diaries of the world’s most fascinating CEOs, experts, therapists, and leaders – with the hope that their lessons will help both you and him live better lives. 
DOAC is a double acronym: Diary Of A CEO, but also Dreamers, Open-minded, Awareness, and Connection.This is your corner of the internet to dream boldly, think openly, expand your awareness, and feel more connected.

My New Book: https://g2ul0.app.link/DOAC
IG: https://www.instagram.com/steven
LI: https://www.linkedin.com/in/stevenbartlett-123

Are you unknowingly damaging your brain and raising your cancer risk with just one drink? Discover the alarming truth about alcohol from Dr. Sarah Wakeman, what every adult needs to know now.

Dr. Sarah Wakeman is senior medical director for substance use disorder at Mass General Brigham healthcare system, the number one research system in the U.S. She is also the Medical Director of the Mass General Hospital Addiction Consult Team and Assistant Professor of Medicine at Harvard Medical School. 

She explains: 

How alcohol is hijacking your dopamine system.

Why no amount of alcohol is good for your brain.

The shocking truth about moderate drinking.

How doctors are failing addiction patients on a daily basis.

Why 1 in 3 people will struggle with alcohol.

00:00 Intro 

02:23 Sarah's Mission 

02:52 Sarah's Education and Experience 

03:40 Issues With Addiction Treatment in the Modern World 

04:31 What Is Addiction? 

05:48 What Things Are Capable of Being Addictive? 

06:47 Physiological Dependence vs. Addiction 

07:25 Scale of the Problem: Why Should People Care? 

08:59 Is Society Getting Better or More Addicted? 

09:32 Substance-Related Deaths During the Pandemic 

10:22 What Drives People to Use Substances? 

12:24 Substances' Effects on the Brain 

14:29 Does Trauma at a Young Age Increase Addiction Risk? 

16:36 The Opposite of Addiction Is Connection 

18:11 Why Addiction Matters to Sarah 

19:02 Living With a Family Member Struggling With Addiction 

20:43 Who Is Sarah Trying to Save? 

22:57 Change Happens When the Pain of Staying the Same Is Greater Than the Pain of Change 

25:53 Misconceptions About Alcohol 

28:15 Is There a Healthy Level of Alcohol Consumption? 

28:50 Is One Drink a Day Safe for Health? 

30:38 Link Between Moderate Drinking and Cancer 

33:23 Types of Cancer Linked to Alcohol Consumption 

34:51 Cancer Risk Among Heavy Drinkers 

35:31 Heavy Drinking and Comorbidities as Cancer Risk Factors 

36:20 How Alcohol Drives Cancer Mechanisms 

38:00 Alcohol and Weight Gain 

38:54 The Role of the Liver 

42:07 Liver's Ability to Regenerate 

46:37 How Alcohol Causes Brain Deterioration 

47:23 Other Organs Affected by Alcohol 

48:00 Alcohol's Impact on the Heart 

49:08 Body Fat Percentage and Alcohol Tolerance 

50:05 Does High Alcohol Tolerance Prevent Organ Damage? 

50:46 What Is a Hangover? 

52:14 Balancing the Risks and Benefits of Alcohol 

53:47 Is Rehab Effective for Addiction? 

56:50 Psychedelic Therapy for Addiction 

57:36 GLP-1 Medications for Addiction Treatment 

59:03 Ads 

59:59 Celebrity Addictions 

1:02:24 Stigma Around Addiction 

1:04:41 Addiction Cases That Broke Sarah's Heart 

1:12:43 Is Empathy Positive Reinforcement for Addicted Individuals? 

1:15:34 Setting Boundaries With an Addicted Person 

1:18:57 Motivational Interviewing to Support Recovery 

1:22:19 Finding Motivation for Positive Change 

1:26:03 Habits to Support Addiction Recovery 

1:29:12 Ads 

1:30:18 Can the Brain Recover From Addiction? 

1:34:55 Unexpected Sources of Addictive Behavior 

1:35:35 How Sarah Copes With Difficult Addiction Cases 

1:37:10 Importance of Language Around Addiction 

1:41:40 How Labels Limit People's Potential 

1:46:05 Sarah's Upcoming Book 

You can find out more about Dr. Sarah’s profile, here: https://bit.ly/4mxu191 

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Research document: 

https://stevenbartlett.com/wp-content/uploads/2025/05/DOAC-Dr-Sarah-Wakeman-Independent-Research-further-reading.pdf

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