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#133 – Manolis Kellis: Biology of Disease

Lex Fridman Podcast

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Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors:
- SEMrush: https://www.semrush.com/partner/lex/ to get a free month of Guru
- Pessimists Archive: https://pessimists.co/
- Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get $200 off
- BetterHelp: https://betterhelp.com/lex to get 10% off

EPISODE LINKS:
Manolis Website: http://web.mit.edu/manoli/
Manolis Twitter: https://twitter.com/manoliskellis
Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA
Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis

PODCAST INFO:
Podcast website: https://lexfridman.com/podcast
Apple Podcasts: https://apple.co/2lwqZIr
Spotify: https://spoti.fi/2nEwCF8
RSS: https://lexfridman.com/feed/podcast/
YouTube Full Episodes: https://youtube.com/lexfridman
YouTube Clips: https://youtube.com/lexclips

SUPPORT & CONNECT:
- Check out the sponsors above, it's the best way to support this podcast
- Support on Patreon: https://www.patreon.com/lexfridman
- Twitter: https://twitter.com/lexfridman
- Instagram: https://www.instagram.com/lexfridman
- LinkedIn: https://www.linkedin.com/in/lexfridman
- Facebook: https://www.facebook.com/LexFridmanPage
- Medium: https://medium.com/@lexfridman

OUTLINE:
Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 - Introduction
08:05 - Molecular basis for human disease
32:04 - Deadliest diseases
37:47 - Genetic component of diseases
46:38 - Genetic understanding of disease
1:02:25 - Unified theory of human disease
1:08:26 - Genome circuitry
1:33:29 - CRISPR
1:45:06 - Mitochondria
1:53:10 - Future of biology research
2:22:46 - The genetic circuitry of disease

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors: 
– SEMrush: <a href="https://www.semrush.com/partner/lex/">https://www.semrush.com/partner/lex/</a> to get a free month of Guru 
– Pessimists Archive: <a href="https://pessimists.co/">https://pessimists.co/</a> 
– Eight Sleep: <a href="https://www.eightsleep.com/lex">https://www.eightsleep.com/lex</a> and use code LEX to get $200 off 
– BetterHelp: <a href="https://betterhelp.com/lex">https://betterhelp.com/lex</a> to get 10% off
EPISODE LINKS: 
Manolis Website: <a href="http://web.mit.edu/manoli/">http://web.mit.edu/manoli/</a> 
Manolis Twitter: <a href="https://twitter.com/manoliskellis">https://twitter.com/manoliskellis</a> 
Manolis YouTube: <a href="https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA">https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA</a> 
Manolis Wikipedia: <a href="https://en.wikipedia.org/wiki/Manolis_Kellis">https://en.wikipedia.org/wiki/Manolis_Kellis</a>
PODCAST INFO: 
Podcast website: <a href="https://lexfridman.com/podcast">https://lexfridman.com/podcast</a> 
Apple Podcasts: <a href="https://apple.co/2lwqZIr">https://apple.co/2lwqZIr</a> 
Spotify: <a href="https://spoti.fi/2nEwCF8">https://spoti.fi/2nEwCF8</a> 
RSS: <a href="https://lexfridman.com/feed/podcast/">https://lexfridman.com/feed/podcast/</a> 
YouTube Full Episodes: <a href="https://youtube.com/lexfridman">https://youtube.com/lexfridman</a> 
YouTube Clips: <a href="https://youtube.com/lexclips">https://youtube.com/lexclips</a>
SUPPORT & CONNECT: 
– Check out the sponsors above, it’s the best way to support this podcast 
– Support on Patreon: <a href="https://www.patreon.com/lexfridman">https://www.patreon.com/lexfridman</a> 
– Twitter: <a href="https://twitter.com/lexfridman">https://twitter.com/lexfridman</a> 
– Instagram: <a href="https://www.instagram.com/lexfridman">https://www.instagram.com/lexfridman</a> 
– LinkedIn: <a href="https://www.linkedin.com/in/lexfridman">https://www.linkedin.com/in/lexfridman</a> 
– Facebook: <a href="https://www.facebook.com/LexFridmanPage">https://www.facebook.com/LexFridmanPage</a> 
– Medium: <a href="https://medium.com/@lexfridman">https://medium.com/@lexfridman</a>
OUTLINE: 
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. 
00:00 – Introduction 
08:05 – Molecular basis for human disease 
32:04 – Deadliest diseases 
37:47 – Genetic component of diseases 
46:38 – Genetic understanding of disease 
1:02:25 – Unified theory of human disease 
1:08:26 – Genome circuitry 
1:33:29 – CRISPR 
1:45:06 – Mitochondria 
1:53:10 – Future of biology research 
2:22:46 – The genetic circuitry of disease

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#133 – Manolis Kellis: Biology of Disease

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